Chromatin remodeling in neural development and plasticity

Jenny Hsieh; Fred H. Gage

doi:10.1016/j.ceb.2005.09.002

Chromatin remodeling in neural development and plasticity

Jenny Hsieh, Fred H. Gage

Research output: Contribution to journal › Review article › peer-review

195 Scopus citations

Abstract

Neural stem cells generate distinct cell types for tissue formation and cell replacement during development and throughout adulthood. Neural development and plasticity are determined by both extrinsic and intrinsic factors that interface to regulate gene programs for controlling neuronal cell fate and function. Recent reports have shown that chromatin remodeling and epigenetic gene regulation play an important role in such diverse areas as neural cell fate specification and synaptic development and function. These epigenetic mechanisms include cell-type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and the activity of retrotransposons.

Original language	English (US)
Pages (from-to)	664-671
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.ceb.2005.09.002
State	Published - Dec 2005

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2005.09.002

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abstract = "Neural stem cells generate distinct cell types for tissue formation and cell replacement during development and throughout adulthood. Neural development and plasticity are determined by both extrinsic and intrinsic factors that interface to regulate gene programs for controlling neuronal cell fate and function. Recent reports have shown that chromatin remodeling and epigenetic gene regulation play an important role in such diverse areas as neural cell fate specification and synaptic development and function. These epigenetic mechanisms include cell-type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and the activity of retrotransposons.",

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AB - Neural stem cells generate distinct cell types for tissue formation and cell replacement during development and throughout adulthood. Neural development and plasticity are determined by both extrinsic and intrinsic factors that interface to regulate gene programs for controlling neuronal cell fate and function. Recent reports have shown that chromatin remodeling and epigenetic gene regulation play an important role in such diverse areas as neural cell fate specification and synaptic development and function. These epigenetic mechanisms include cell-type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and the activity of retrotransposons.

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Chromatin remodeling in neural development and plasticity

Abstract

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