We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Nov 11 1986|
- Alzheimer's disease
- Choline acetyltransferase
- Neuritic plaque
ASJC Scopus subject areas