TY - JOUR
T1 - Choline Acetyltransferase and Acetylcholinesterase
T2 - Their Role in the Causes of Myasthenia Gravis
AU - Gentner, D. R.
AU - Rosenberg, R. N.
PY - 1972/12
Y1 - 1972/12
N2 - Choline acetyltransferase, acetylcholinesterase, and pseudocholinesterase levels were measured in needle biopsy samples of deltoid muscle from subjects with myasthenia gravis and from normal controls. Choline acetyltransferase activities were about 30% lower and acetylcholinesterase activities about 45% lower in myasthenics as compared with controls. These decreased activities, however, are not significant in the cause of the disease; it is postulated that the primary defect at the neuromuscular junction may be the presence of a false transmitter in the synaptic vesicle or defective release of the vesicle contents at the synaptic cleft.
AB - Choline acetyltransferase, acetylcholinesterase, and pseudocholinesterase levels were measured in needle biopsy samples of deltoid muscle from subjects with myasthenia gravis and from normal controls. Choline acetyltransferase activities were about 30% lower and acetylcholinesterase activities about 45% lower in myasthenics as compared with controls. These decreased activities, however, are not significant in the cause of the disease; it is postulated that the primary defect at the neuromuscular junction may be the presence of a false transmitter in the synaptic vesicle or defective release of the vesicle contents at the synaptic cleft.
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U2 - 10.1001/archneur.1972.00490180057013
DO - 10.1001/archneur.1972.00490180057013
M3 - Article
C2 - 4343459
AN - SCOPUS:0015482131
SN - 0003-9942
VL - 27
SP - 521
EP - 525
JO - Archives of neurology
JF - Archives of neurology
IS - 6
ER -