TY - JOUR
T1 - Cholecystokinin and Neurotensin Gradients in Human CSF
AU - Tamminga, C. A.
AU - LeWitt, P. A.
AU - Chase, T. N.
PY - 1985/4
Y1 - 1985/4
N2 - In successive samples of human lunbar CSF, concentrations of two neurally active peptides, cholecystokinin (CCK) and neurotensin (NT), were compared with levels of homovanillic acid (HVA), the major metabolite of dopamine. Although HVA values progressively increased between the first and 20th milliliter samples, no significant change occurred in the concentration of either peptide. Thus, lumbar CSF levels of CCK and NT, unlike levels of HVA, may not closely reflect amounts of these peptides in supraspinal CSF or brain.
AB - In successive samples of human lunbar CSF, concentrations of two neurally active peptides, cholecystokinin (CCK) and neurotensin (NT), were compared with levels of homovanillic acid (HVA), the major metabolite of dopamine. Although HVA values progressively increased between the first and 20th milliliter samples, no significant change occurred in the concentration of either peptide. Thus, lumbar CSF levels of CCK and NT, unlike levels of HVA, may not closely reflect amounts of these peptides in supraspinal CSF or brain.
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U2 - 10.1001/archneur.1985.04060040064013
DO - 10.1001/archneur.1985.04060040064013
M3 - Article
C2 - 3985812
AN - SCOPUS:0021953175
SN - 0003-9942
VL - 42
SP - 354
EP - 355
JO - Archives of neurology
JF - Archives of neurology
IS - 4
ER -