Cholecystokinin and Neurotensin Gradients in Human CSF

C. A. Tamminga, P. A. LeWitt, T. N. Chase

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


In successive samples of human lunbar CSF, concentrations of two neurally active peptides, cholecystokinin (CCK) and neurotensin (NT), were compared with levels of homovanillic acid (HVA), the major metabolite of dopamine. Although HVA values progressively increased between the first and 20th milliliter samples, no significant change occurred in the concentration of either peptide. Thus, lumbar CSF levels of CCK and NT, unlike levels of HVA, may not closely reflect amounts of these peptides in supraspinal CSF or brain.

Original languageEnglish (US)
Pages (from-to)354-355
Number of pages2
JournalArchives of neurology
Issue number4
StatePublished - Apr 1985

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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