Chloral hydrate toxicity in a preterm infant

A. R. Laptook, C. R. Rosenfeld

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Ventilator care in premature infants with hyaline membrane disease (HMD) may be complicated by episodes of irritability and 'fighting' the respirator, resulting in significant hypoxemia. Neuromuscular blockade with pharmacologic agents such as pancuronium bromide is frequently used to manage this problem [Crone and Favorito, 1980]. This therapy results in the loss of important clinical signs, such as alterations in muscle tone and spontaneous movements, which are important in monitoring the critically ill newborn. As a result of these considerations, we occasionally have utilized the sedative-hypnotic effects of chloral hydrate to achieve adequate ventilation and oxygenation in these infants. We report, however, a case of a preterm infant who developed severe chloral hydrate toxicity after its administration as an adjunct to the treatment of HMD.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalPediatric Pharmacology
Issue number3
StatePublished - Dec 1 1984

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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