TY - JOUR
T1 - Chimeric Antigen Receptor T-Cell Therapy in the Outpatient Setting
T2 - An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy
AU - Oluwole, Olalekan O.
AU - Dholaria, Bhagirathbhai
AU - Knight, Tristan E.
AU - Jain, Tania
AU - Locke, Frederick L.
AU - Ramsdell, Linda
AU - Nikiforow, Sarah
AU - Hashmi, Hamza
AU - Mooney, Kathy
AU - Bhaskar, Shakthi T.
AU - Morris, Katrina
AU - Gatwood, Katie
AU - Baer, Brittney
AU - Anderson, Larry D.
AU - Hamadani, Mehdi
N1 - Publisher Copyright:
© 2023
PY - 2024/2
Y1 - 2024/2
N2 - The first series of chimeric antigen receptor T (CAR-T) cell therapy products were approved in 2017 to 2019 and have shown remarkable efficacy in both clinical trials and the real-world setting, but at the cost of prolonged patient hospitalization. As the toxicity management protocols were refined, the concept of cellular therapy administered in the outpatient setting gained steam, and single institutions began to perform certain aspects of CAR-T monitoring in the outpatient setting for select patients. However, there are many considerations for a successful outpatient program. In anticipation of increasing use of CAR-T-cell therapy in the outpatient setting as a mechanism to overcome frequent hospital bed shortages and high cost of inpatient care, the American Society for Transplantation and Cellular Therapy convened a group of experts in hematology, oncology, and cellular therapy to provide a comprehensive review of the existing publications on outpatient CAR-T cell therapy, discuss selected ongoing clinical trials of outpatient CAR-T, and describe strategies to optimize safety without compromising efficacy for patients treated and monitored in the outpatient setting.
AB - The first series of chimeric antigen receptor T (CAR-T) cell therapy products were approved in 2017 to 2019 and have shown remarkable efficacy in both clinical trials and the real-world setting, but at the cost of prolonged patient hospitalization. As the toxicity management protocols were refined, the concept of cellular therapy administered in the outpatient setting gained steam, and single institutions began to perform certain aspects of CAR-T monitoring in the outpatient setting for select patients. However, there are many considerations for a successful outpatient program. In anticipation of increasing use of CAR-T-cell therapy in the outpatient setting as a mechanism to overcome frequent hospital bed shortages and high cost of inpatient care, the American Society for Transplantation and Cellular Therapy convened a group of experts in hematology, oncology, and cellular therapy to provide a comprehensive review of the existing publications on outpatient CAR-T cell therapy, discuss selected ongoing clinical trials of outpatient CAR-T, and describe strategies to optimize safety without compromising efficacy for patients treated and monitored in the outpatient setting.
KW - Cellular therapy
KW - Chimeric antigen receptor (CAR) T cells
KW - Cytokine release syndrome (CRS)
KW - Immune effector cell-associated neurotoxicity syndrome (ICANS)
KW - Outpatient monitoring
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U2 - 10.1016/j.jtct.2023.11.008
DO - 10.1016/j.jtct.2023.11.008
M3 - Article
C2 - 37951502
AN - SCOPUS:85179667722
SN - 2666-6375
VL - 30
SP - 131
EP - 142
JO - Transplantation and Cellular Therapy
JF - Transplantation and Cellular Therapy
IS - 2
ER -