TY - JOUR
T1 - Chest compression rates and survival following out-of-hospital cardiac arrest
AU - Idris, Ahamed H.
AU - Guffey, Danielle
AU - Pepe, Paul E.
AU - Brown, Siobhan P.
AU - Brooks, Steven C.
AU - Callaway, Clifton W.
AU - Christenson, Jim
AU - Davis, Daniel P.
AU - Daya, Mohamud R.
AU - Gray, Randal
AU - Kudenchuk, Peter J.
AU - Larsen, Jonathan
AU - Lin, Steve
AU - Menegazzi, James J.
AU - Sheehan, Kellie
AU - Sopko, George
AU - Stiell, Ian
AU - Nichol, Graham
AU - Aufderheide, Tom P.
N1 - Publisher Copyright:
Copyright © 2015 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
PY - 2015/4/20
Y1 - 2015/4/20
N2 - Objective: Guidelines for cardiopulmonary resuscitation recommend a chest compression rate of at least 100 compressions/min. A recent clinical study reported optimal return of spontaneous circulation with rates between 100 and 120/min during cardiopulmonary resuscitation for out-of-hospital cardiac arrest. However, the relationship between compression rate and survival is still undetermined. Design: Prospective, observational study. Setting: Data is from the Resuscitation Outcomes Consortium Prehospital Resuscitation IMpedance threshold device and Early versus Delayed analysis clinical trial. Participants: Adults with out-of-hospital cardiac arrest treated by emergency medical service providers. Interventions: None. Measurements Main Results: Data were abstracted from monitor-defibrillator recordings for the first five minutes of emergency medical service cardiopulmonary resuscitation. Multiple logistic regression assessed odds ratio for survival by compression rate categories (<80, 80-99, 100-119, 120-139, ≥140), both unadjusted and adjusted for sex, age, witnessed status, attempted bystander cardiopulmonary resuscitation, location of arrest, chest compression fraction and depth, first rhythm, and study site. Compression rate data were available for 10,371 patients; 6,399 also had chest compression fraction and depth data. Age (mean ± sd) was 67 ± 16 years. Chest compression rate was 111 ± 19 per minute, compression fraction was 0.70 ± 0.17, and compression depth was 42 ± 12 mm. Circulation was restored in 34%; 9% survived to hospital discharge. After adjustment for covariates without chest compression depth and fraction (n = 10,371), a global test found no significant relationship between compression rate and survival (p = 0.19). However, after adjustment for covariates including chest compression depth and fraction (n = 6,399), the global test found a significant relationship between compression rate and survival (p = 0.02), with the reference group (100-119 compressions/min) having the greatest likelihood for survival. Conclusions: After adjustment for chest compression fraction and depth, compression rates between 100 and 120 per minute were associated with greatest survival to hospital discharge.
AB - Objective: Guidelines for cardiopulmonary resuscitation recommend a chest compression rate of at least 100 compressions/min. A recent clinical study reported optimal return of spontaneous circulation with rates between 100 and 120/min during cardiopulmonary resuscitation for out-of-hospital cardiac arrest. However, the relationship between compression rate and survival is still undetermined. Design: Prospective, observational study. Setting: Data is from the Resuscitation Outcomes Consortium Prehospital Resuscitation IMpedance threshold device and Early versus Delayed analysis clinical trial. Participants: Adults with out-of-hospital cardiac arrest treated by emergency medical service providers. Interventions: None. Measurements Main Results: Data were abstracted from monitor-defibrillator recordings for the first five minutes of emergency medical service cardiopulmonary resuscitation. Multiple logistic regression assessed odds ratio for survival by compression rate categories (<80, 80-99, 100-119, 120-139, ≥140), both unadjusted and adjusted for sex, age, witnessed status, attempted bystander cardiopulmonary resuscitation, location of arrest, chest compression fraction and depth, first rhythm, and study site. Compression rate data were available for 10,371 patients; 6,399 also had chest compression fraction and depth data. Age (mean ± sd) was 67 ± 16 years. Chest compression rate was 111 ± 19 per minute, compression fraction was 0.70 ± 0.17, and compression depth was 42 ± 12 mm. Circulation was restored in 34%; 9% survived to hospital discharge. After adjustment for covariates without chest compression depth and fraction (n = 10,371), a global test found no significant relationship between compression rate and survival (p = 0.19). However, after adjustment for covariates including chest compression depth and fraction (n = 6,399), the global test found a significant relationship between compression rate and survival (p = 0.02), with the reference group (100-119 compressions/min) having the greatest likelihood for survival. Conclusions: After adjustment for chest compression fraction and depth, compression rates between 100 and 120 per minute were associated with greatest survival to hospital discharge.
KW - Cardiac arrest
KW - Cardiopulmonary resuscitation
KW - Compression rate
KW - Guidelines
KW - Heart arrest
KW - Outcomes
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U2 - 10.1097/CCM.0000000000000824
DO - 10.1097/CCM.0000000000000824
M3 - Article
C2 - 25565457
AN - SCOPUS:84929505283
SN - 0090-3493
VL - 43
SP - 840
EP - 848
JO - Critical care medicine
JF - Critical care medicine
IS - 4
ER -