Chemotherapy for Generalized Infantile Myofibromatosis with Visceral Involvement

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19 Scopus citations


Infantile myofibromatosis (IM) is most commonly limited to cutaneous lesions that resolve spontaneously. However, generalized IM with visceral involvement, which has a reported mortality rate as high as 73%, has been successfully treated with a combination of methotrexate and vinblastine. Here we report the further efficacy of low-dose methotrexate and vinblastine in 2 pediatric patients with IM and visceral involvement and review the literature describing chemotherapy for these patients.

Original languageEnglish (US)
Pages (from-to)402-405
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Issue number5
StatePublished - Jul 11 2015


  • infantile myofibromatosis
  • methotrexate
  • pediatrics
  • vinblastine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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