Chemically induced pluripotent stem cells (CiPSCs): A transgene-free approach

Shigeo Masuda; Jun Wu; Tomoaki Hishida; Ganesh N. Pandian; Hiroshi Sugiyama; Juan Carlos Izpisua Belmonte

doi:10.1093/jmcb/mjt034

Chemically induced pluripotent stem cells (CiPSCs): A transgene-free approach

Shigeo Masuda, Jun Wu, Tomoaki Hishida, Ganesh N. Pandian, Hiroshi Sugiyama, Juan Carlos Izpisua Belmonte

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.

Original language	English (US)
Pages (from-to)	354-355
Number of pages	2
Journal	Journal of molecular cell biology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1093/jmcb/mjt034
State	Published - Oct 2013
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cell Biology

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10.1093/jmcb/mjt034

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abstract = "Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.",

author = "Shigeo Masuda and Jun Wu and Tomoaki Hishida and Pandian, {Ganesh N.} and Hiroshi Sugiyama and {Izpisua Belmonte}, {Juan Carlos}",

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AU - Sugiyama, Hiroshi

AU - Izpisua Belmonte, Juan Carlos

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Chemically induced pluripotent stem cells (CiPSCs): A transgene-free approach

Abstract

ASJC Scopus subject areas

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