Chemical models of anxiety: Evidence for diagnostic and neurotransmitter specificity

Thomas W. Uhde, Manuel E. Tancer, George N M Gurguis

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The implications of theory-based versus data-based approaches to treatment and the evidence for the diagnostic and neurotransmitter specificity of the anxiety disorders are discussed within the context of old and new chemical models of anxiety. The authors suggest that the interplay between clinical observation, formation of testable hypotheses and data-based experimentation, will result in the identification of clinical and biological predictors of drug response and the development of more effective and better tolerated drug therapies.

Original languageEnglish (US)
Pages (from-to)367-384
Number of pages18
JournalInternational Review of Psychiatry
Issue number3-4
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Psychiatry and Mental health


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