TY - JOUR
T1 - Characterization of Mild Cognitive Impairment and Dementia among Community-Dwelling Mexican Americans and Non-Hispanic Whites
AU - HABS-HD Study Team
AU - O'Bryant, Sid E.
AU - Petersen, Melissa
AU - Hall, James
AU - Johnson, Leigh A.
AU - Barber, Robert
AU - Phillips, Nicole
AU - Braskie, Meredith N.
AU - Yaffe, Kristine
AU - Rissman, Robert
AU - Toga, Arthur
AU - King, Kevin
AU - Borzage, Matthew
AU - Palmer, Raymond
AU - Shi, Yonggang
AU - Zhang, Fan
AU - Nandy, Rajesh
AU - McColl, Roderick
AU - Mason, David
AU - Christian, Bradley
AU - Philips, Nicole
AU - Large, Stephanie
N1 - Publisher Copyright:
© 2022 - IOS Press. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Background: Despite tremendous advancements in the field, our understanding of mild cognitive impairment (MCI) and Alzheimer's disease (AD) among Mexican Americans remains limited. Objective: The aim of this study was to characterize MCI and dementia among Mexican Americans and non-Hispanic whites. Methods: Baseline data were analyzed from n=1,705 (n=890 Mexican American; n=815 non-Hispanic white) participants enrolled in the Health and Aging Brain Study-Health Disparities (HABS-HD). Results: Among Mexican Americans, age (OR=1.07), depression (OR=1.09), and MRI-based neurodegeneration (OR=0.01) were associated with dementia, but none of these factors were associated with MCI. Among non-Hispanic whites, male gender (OR=0.33), neighborhood deprivation (OR=1.34), depression (OR=1.09), and MRI-based neurodegeneration (OR=0.03) were associated with MCI, while depression (OR=1.09) and APOE ϵ4 genotype (OR=4.38) were associated with dementia. Conclusion: Findings from this study revealed that the demographic, clinical, sociocultural and biomarker characteristics of MCI and dementia are different among Mexican Americans as compared to non-Hispanic whites.
AB - Background: Despite tremendous advancements in the field, our understanding of mild cognitive impairment (MCI) and Alzheimer's disease (AD) among Mexican Americans remains limited. Objective: The aim of this study was to characterize MCI and dementia among Mexican Americans and non-Hispanic whites. Methods: Baseline data were analyzed from n=1,705 (n=890 Mexican American; n=815 non-Hispanic white) participants enrolled in the Health and Aging Brain Study-Health Disparities (HABS-HD). Results: Among Mexican Americans, age (OR=1.07), depression (OR=1.09), and MRI-based neurodegeneration (OR=0.01) were associated with dementia, but none of these factors were associated with MCI. Among non-Hispanic whites, male gender (OR=0.33), neighborhood deprivation (OR=1.34), depression (OR=1.09), and MRI-based neurodegeneration (OR=0.03) were associated with MCI, while depression (OR=1.09) and APOE ϵ4 genotype (OR=4.38) were associated with dementia. Conclusion: Findings from this study revealed that the demographic, clinical, sociocultural and biomarker characteristics of MCI and dementia are different among Mexican Americans as compared to non-Hispanic whites.
KW - Alzheimer's disease
KW - Hispanic
KW - health disparities
KW - mild cognitive impairment
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U2 - 10.3233/JAD-220300
DO - 10.3233/JAD-220300
M3 - Article
C2 - 36189588
AN - SCOPUS:85141938865
SN - 1387-2877
VL - 90
SP - 905
EP - 915
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 2
ER -