Characteristic performance investigation of a photon counting detector for x-ray fluorescence imaging applications

Liqiang Ren, Muhammad U. Ghani, Di Wu, Yuhua Li, Wei R. Chen, Ge Wang, Bin Zheng, Hong Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


The characteristic performance of a photon counting detector for X-ray fluorescence (XRF) imaging of gold nanoparticles (GNPs) is investigated. The investigations are first performed in three aspects: X-ray photon energy (keV) to pulse height (mV) conversion, noise floor determination, and linear detection ranges. Then, theoretical models are applied to evaluate the detection efficiency of X-ray photons with respect to an increased incident photon rate. Last, through exciting 100% pure GNPs by a conventional X-ray tube operated at a voltage of 110kVp, we acquire XRF spectrum in the threshold mode, based on which multi-energy thresholds are selected for XRF imaging of GNPs with low concentrations. Preliminary XRF imaging results of GNPs obtained in the imaging mode are presented and analyzed. This investigation study is essential to the development of fast and accurate XRF imaging of GNPs as well as other high atomic (Z) imaging contrast agents absorbed in cancerous cells.

Original languageEnglish (US)
Title of host publicationBiophotonics and Immune Responses XII
EditorsWei R. Chen
ISBN (Electronic)9781510605718
StatePublished - 2017
Externally publishedYes
EventBiophotonics and Immune Responses XII - San Francisco, United States
Duration: Jan 30 2017 → …

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceBiophotonics and Immune Responses XII
Country/TerritoryUnited States
CitySan Francisco
Period1/30/17 → …


  • Characteristic performance investigation
  • Gold nanoparticles (GNPs)
  • Photon counting detector
  • X-ray fluorescence (XRF)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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