Characterisation of an outer membrane protein of Moraxella catarrhalis

Kate E. Mathers, David Goldblatt, Christoph Aebi, Rong Hua Yu, Anthony B. Schryvers, Eric J. Hansen

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


To elucidate potential vaccine antigens, Moraxella catarrhalis outer membrane proteins (OMPs) were studied. We have previously shown an OMP to be a target for human IgG and have now further characterised this OMP which appears to have a molecular mass of 84 kDa and to be distinct from the 81-kDa OMP, CopB. Human transferrin was shown to bind the 84-kDa Chip alone. N-terminal sequencing of this OMP and purified M. catarrhalis transferrin binding protein B (TbpB) revealed homolog both with each other and with the TbpB of Haemophilus influenzae and Neisseria meningitidis. Adsorption of human anti-serum with purified TbpB from two M. catarrhalis strains abolished or reduced binding of IgG to the 84-kDa OMP from thee M. catarrhalis isolates. IgG binding to CopB was unaffected. It is clear that the 84-kDa OMP is distinct from CopB and is a likely homologue of TbpB.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalFEMS Immunology and Medical Microbiology
Issue number3
StatePublished - Nov 1997


  • Immunoglobulin G
  • Moraxella catarrhalis
  • Outer membrane protein
  • Transferrin binding protein

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases


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