Chapter 3 Signal transduction mechanisms in memory disorders

Sara C. Shalin, Regula Egli, Shari G. Birnbaum, Tania L. Roth, Jonathan M. Levenson, J. David Sweatt

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


This chapter explores some of the molecular events contributing to memory formation and how, when these events malfunction, disturbances in memory occur. After a brief discussion of signaling in the hippocampus, we will explore the topics of human mental retardation syndromes that involve disruption of these processes, including Angelman syndrome (AS), Neurofibromatosis 1 (NF1)-associated learning disorders, Coffin-Lowry syndrome (CLS), Rubinstein-Taybi syndrome (RTS), and Rett syndrome (RTT).

Original languageEnglish (US)
Pages (from-to)25-41,384
JournalProgress in Brain Research
StatePublished - 2006


  • CBP
  • CaMKII
  • ERK
  • MAPK
  • MeCP2
  • NF1
  • RSK
  • epigenetics
  • learning
  • mental retardation

ASJC Scopus subject areas

  • Neuroscience(all)


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