Chapter 25 - Techniques of Experimentation

Michael R. Talcott, Walter Akers, Robert P. Marini

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Since the publication of the second edition of this text in 2004, the primacy of genetically engineered animals has been firmly established. The creation of transgenic and knockout mice with a wide variety of genotypes has revolutionized the study of many disease entities, some of which could previously be modeled only in larger animal species. The complete sequencing of a number of pertinent genomes, including the mouse, guinea pig, rabbit, and dog, along with the associated emerging fields of transcriptomics, proteomics, and metabolomics, has led to an increasingly insightful and focused inquiry into the nature of life and disease. A foundation for these inquiries is the enduring need to define and manipulate the animal model, and the comparative medicine scientist or clinician is the agent who develops and implements the techniques and procedures that are the essential tools for discovery.

Original languageEnglish (US)
Title of host publicationLaboratory Animal Medicine
Subtitle of host publicationThird Edition
PublisherElsevier Inc.
Number of pages62
ISBN (Print)9780124095274
StatePublished - Jan 1 2015
Externally publishedYes


  • Blood collection
  • Cardiovascular techniques
  • Digestive system techniques
  • Endocrine system techniques
  • Imaging techniques
  • Intraperitoneal injection
  • Intravenous injection
  • Neurosurgical techniques
  • Orthopedic procedures
  • Radiotelemetry
  • Reproductive system techniques
  • Respiratory system techniques
  • Subcutaneous and intramuscular injection
  • Thymectomy
  • Tumor transplantation
  • Urinary system techniques
  • Vascular cannulation

ASJC Scopus subject areas

  • veterinary(all)


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