Chapter 1: General Synthetic and Physical Methods

Quyen N. Do, James S. Ratnakar, Zoltán Kovács, Gyula Tircsó, Ferenc Krisztián Kálmán, Zsolt Baranyai, Erno Brücher, Imre Tóth

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Contrast agents for magnetic resonance imaging (MRI) currently used and approved by the Food and Drug Administration (FDA) of the United States of America are GdIII-based. Yet, GdIII complexes are only one class of contrast agents for MRI. The fundamentals described in this chapter are intended to assist with the design of future imaging agents for MRI. Ligands affect not only relaxivity but also thermodynamic stability and kinetic inertness of GdIII complexes, which in turn affect the safety profiles of contrast agents. Divided into four sections, this chapter describes syntheses and characterization of ligands and metal complexes as well as the determination of the stability and lability of metal complexes.

Original languageEnglish (US)
Title of host publicationNew Developments in NMR
EditorsValerie C. Pierre, Matthew J. Allen
PublisherRoyal Society of Chemistry
Number of pages120
ISBN (Electronic)9781782624479, 9781782628545, 9781849736435, 9781849739139
ISBN (Print)9781788010863, 9781788011044
StatePublished - 2018

Publication series

NameNew Developments in NMR
ISSN (Print)2044-253X
ISSN (Electronic)2044-2548

ASJC Scopus subject areas

  • Analytical Chemistry
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy


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