Changes in brain water diffusion during childhood

M. C. Morriss; R. A. Zimmerman; L. T. Bilaniuk; J. V. Hunter; J. C. Haselgrove

doi:10.1007/s002340050869

Changes in brain water diffusion during childhood

M. C. Morriss, R. A. Zimmerman, L. T. Bilaniuk, J. V. Hunter, J. C. Haselgrove

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160 Scopus citations

Abstract

We studied the changes in brain water diffusion in childhood as seen on diffusion-weighted MRI in 30 children from 1 day of life to 17 years to provide a data base and to investigate the correlation of diffusion changes with known patterns of white matter maturation. The apparent diffusion coefficient (ADC) and apparent anisotropy (AA) were calculated in numerous regions of the brain to include major white matter tracts and gray matter. ADC and AA values were directly related to the structural maturity and compactness of the white matter tracts and changed with aging in a way that predated early myelination markers such as signal change on T1- or T2-weighted images. Diffusion of water is sensitive to structural changes in the brain such as white matter maturation and may be useful in investigating white matter disorders.

Original language	English (US)
Pages (from-to)	929-934
Number of pages	6
Journal	Neuroradiology
Volume	41
Issue number	12
DOIs	https://doi.org/10.1007/s002340050869
State	Published - Dec 1999

Keywords

Children
Magnetic resonance imaging, diffusion weighted
Myelination

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1007/s002340050869

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title = "Changes in brain water diffusion during childhood",

abstract = "We studied the changes in brain water diffusion in childhood as seen on diffusion-weighted MRI in 30 children from 1 day of life to 17 years to provide a data base and to investigate the correlation of diffusion changes with known patterns of white matter maturation. The apparent diffusion coefficient (ADC) and apparent anisotropy (AA) were calculated in numerous regions of the brain to include major white matter tracts and gray matter. ADC and AA values were directly related to the structural maturity and compactness of the white matter tracts and changed with aging in a way that predated early myelination markers such as signal change on T1- or T2-weighted images. Diffusion of water is sensitive to structural changes in the brain such as white matter maturation and may be useful in investigating white matter disorders.",

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AU - Morriss, M. C.

AU - Zimmerman, R. A.

AU - Bilaniuk, L. T.

AU - Hunter, J. V.

AU - Haselgrove, J. C.

PY - 1999/12

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AB - We studied the changes in brain water diffusion in childhood as seen on diffusion-weighted MRI in 30 children from 1 day of life to 17 years to provide a data base and to investigate the correlation of diffusion changes with known patterns of white matter maturation. The apparent diffusion coefficient (ADC) and apparent anisotropy (AA) were calculated in numerous regions of the brain to include major white matter tracts and gray matter. ADC and AA values were directly related to the structural maturity and compactness of the white matter tracts and changed with aging in a way that predated early myelination markers such as signal change on T1- or T2-weighted images. Diffusion of water is sensitive to structural changes in the brain such as white matter maturation and may be useful in investigating white matter disorders.

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KW - Magnetic resonance imaging, diffusion weighted

KW - Myelination

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Changes in brain water diffusion during childhood

Abstract

Keywords

ASJC Scopus subject areas

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