Change in seizure threshold during electroconvulsive therapy

Max Fink; Georgios Petrides; Charles Kellner; Martina Mueller; Rebecca Knapp; Mustafa M. Husain; Keith Rasmussen; Teri Rummans; Kevin O'Connor

doi:10.1097/YCT.0b013e31815f65b9

Change in seizure threshold during electroconvulsive therapy

Max Fink, Georgios Petrides, Charles Kellner, Martina Mueller, Rebecca Knapp, Mustafa M. Husain, Keith Rasmussen, Teri Rummans, Kevin O'Connor

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The seizure threshold (ST) is a measure of the minimum electrical energy necessary to induce a grand mal seizure. Dose titration of the ST has been suggested to optimize stimulus dosing in electroconvulsive therapy (ECT). The change in ST with remission is examined in a large sample of unipolar depressed patients. Methods: In a study of continuation treatments after successful ECT, the ST was determined at the first treatment and again 1 week after remission using a conventional ST measurement protocol. Patients were treated with bilateral electrode placement at 150% above the measured ST. Results: In 80 subjects, the ST measured the same in 70%, increased in 21%, and decreased in 9% at remission. Conclusions: In a study of bilateral ECT, the ST did not rise conclusively with remission.

Original language	English (US)
Pages (from-to)	114-116
Number of pages	3
Journal	Journal of ECT
Volume	24
Issue number	2
DOIs	https://doi.org/10.1097/YCT.0b013e31815f65b9
State	Published - Jun 1 2008

Keywords

Bilateral ECT
Major depression
Seizure threshold

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Psychiatry and Mental health

Access to Document

10.1097/YCT.0b013e31815f65b9

Cite this

@article{2a21ea1e0f534c7193124f74d12e9fbc,

title = "Change in seizure threshold during electroconvulsive therapy",

abstract = "The seizure threshold (ST) is a measure of the minimum electrical energy necessary to induce a grand mal seizure. Dose titration of the ST has been suggested to optimize stimulus dosing in electroconvulsive therapy (ECT). The change in ST with remission is examined in a large sample of unipolar depressed patients. Methods: In a study of continuation treatments after successful ECT, the ST was determined at the first treatment and again 1 week after remission using a conventional ST measurement protocol. Patients were treated with bilateral electrode placement at 150% above the measured ST. Results: In 80 subjects, the ST measured the same in 70%, increased in 21%, and decreased in 9% at remission. Conclusions: In a study of bilateral ECT, the ST did not rise conclusively with remission.",

keywords = "Bilateral ECT, Major depression, Seizure threshold",

author = "Max Fink and Georgios Petrides and Charles Kellner and Martina Mueller and Rebecca Knapp and Husain, {Mustafa M.} and Keith Rasmussen and Teri Rummans and Kevin O'Connor",

year = "2008",

month = jun,

day = "1",

doi = "10.1097/YCT.0b013e31815f65b9",

language = "English (US)",

volume = "24",

pages = "114--116",

journal = "Convulsive Therapy",

issn = "1095-0680",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Change in seizure threshold during electroconvulsive therapy

AU - Fink, Max

AU - Petrides, Georgios

AU - Kellner, Charles

AU - Mueller, Martina

AU - Knapp, Rebecca

AU - Husain, Mustafa M.

AU - Rasmussen, Keith

AU - Rummans, Teri

AU - O'Connor, Kevin

PY - 2008/6/1

Y1 - 2008/6/1

N2 - The seizure threshold (ST) is a measure of the minimum electrical energy necessary to induce a grand mal seizure. Dose titration of the ST has been suggested to optimize stimulus dosing in electroconvulsive therapy (ECT). The change in ST with remission is examined in a large sample of unipolar depressed patients. Methods: In a study of continuation treatments after successful ECT, the ST was determined at the first treatment and again 1 week after remission using a conventional ST measurement protocol. Patients were treated with bilateral electrode placement at 150% above the measured ST. Results: In 80 subjects, the ST measured the same in 70%, increased in 21%, and decreased in 9% at remission. Conclusions: In a study of bilateral ECT, the ST did not rise conclusively with remission.

AB - The seizure threshold (ST) is a measure of the minimum electrical energy necessary to induce a grand mal seizure. Dose titration of the ST has been suggested to optimize stimulus dosing in electroconvulsive therapy (ECT). The change in ST with remission is examined in a large sample of unipolar depressed patients. Methods: In a study of continuation treatments after successful ECT, the ST was determined at the first treatment and again 1 week after remission using a conventional ST measurement protocol. Patients were treated with bilateral electrode placement at 150% above the measured ST. Results: In 80 subjects, the ST measured the same in 70%, increased in 21%, and decreased in 9% at remission. Conclusions: In a study of bilateral ECT, the ST did not rise conclusively with remission.

KW - Bilateral ECT

KW - Major depression

KW - Seizure threshold

UR - http://www.scopus.com/inward/record.url?scp=54049107417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54049107417&partnerID=8YFLogxK

U2 - 10.1097/YCT.0b013e31815f65b9

DO - 10.1097/YCT.0b013e31815f65b9

M3 - Article

C2 - 18580552

AN - SCOPUS:54049107417

SN - 1095-0680

VL - 24

SP - 114

EP - 116

JO - Convulsive Therapy

JF - Convulsive Therapy

IS - 2

ER -

Change in seizure threshold during electroconvulsive therapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this