Change in seizure threshold during electroconvulsive therapy

Max Fink; Georgios Petrides; Charles Kellner; Martina Mueller; Rebecca Knapp; Mustafa M. Husain; Keith Rasmussen; Teri Rummans; Kevin O'Connor

doi:10.1097/YCT.0b013e31815f65b9

Change in seizure threshold during electroconvulsive therapy

Max Fink, Georgios Petrides, Charles Kellner, Martina Mueller, Rebecca Knapp, Mustafa M. Husain, Keith Rasmussen, Teri Rummans, Kevin O'Connor

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The seizure threshold (ST) is a measure of the minimum electrical energy necessary to induce a grand mal seizure. Dose titration of the ST has been suggested to optimize stimulus dosing in electroconvulsive therapy (ECT). The change in ST with remission is examined in a large sample of unipolar depressed patients. Methods: In a study of continuation treatments after successful ECT, the ST was determined at the first treatment and again 1 week after remission using a conventional ST measurement protocol. Patients were treated with bilateral electrode placement at 150% above the measured ST. Results: In 80 subjects, the ST measured the same in 70%, increased in 21%, and decreased in 9% at remission. Conclusions: In a study of bilateral ECT, the ST did not rise conclusively with remission.

Original language	English (US)
Pages (from-to)	114-116
Number of pages	3
Journal	Journal of ECT
Volume	24
Issue number	2
DOIs	https://doi.org/10.1097/YCT.0b013e31815f65b9
State	Published - Jun 2008

Keywords

Bilateral ECT
Major depression
Seizure threshold

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Psychiatry and Mental health

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10.1097/YCT.0b013e31815f65b9

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title = "Change in seizure threshold during electroconvulsive therapy",

abstract = "The seizure threshold (ST) is a measure of the minimum electrical energy necessary to induce a grand mal seizure. Dose titration of the ST has been suggested to optimize stimulus dosing in electroconvulsive therapy (ECT). The change in ST with remission is examined in a large sample of unipolar depressed patients. Methods: In a study of continuation treatments after successful ECT, the ST was determined at the first treatment and again 1 week after remission using a conventional ST measurement protocol. Patients were treated with bilateral electrode placement at 150% above the measured ST. Results: In 80 subjects, the ST measured the same in 70%, increased in 21%, and decreased in 9% at remission. Conclusions: In a study of bilateral ECT, the ST did not rise conclusively with remission.",

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AU - Fink, Max

AU - Petrides, Georgios

AU - Kellner, Charles

AU - Mueller, Martina

AU - Knapp, Rebecca

AU - Husain, Mustafa M.

AU - Rasmussen, Keith

AU - Rummans, Teri

AU - O'Connor, Kevin

PY - 2008/6

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Change in seizure threshold during electroconvulsive therapy

Abstract

Keywords

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