TY - JOUR
T1 - Challenges and opportunities in targeting the costimulation pathway in solid organ transplantation
AU - Wojciechowski, David
AU - Vincenti, Flavio
N1 - Funding Information:
Flavio Vincenti received grant support from Bristol-Myers Squibb, Princeton, New Jersey, USA .
PY - 2011/6
Y1 - 2011/6
N2 - Signaling through the costimulatory pathway is critical in the regulation of T cell activation. Abatacept, a selective costimulatory antagonist FDA approved for the treatment of moderate to severe rheumatoid arthritis, binds to CD80 and CD86 on antigen presenting cells, blocking the interaction with CD28 on T cells. Belatacept, a second generation CTLA4-Ig with 2 amino acid substitutions, has shown considerable promise in clinical transplantation as part of a maintenance immunosuppression regimen. This review will summarize the role of costimulation in T cell activation, detail the development of costimulation antagonists and highlight the pertinent clinical trials completed and ongoing utilizing belatacept as part of an immunosuppressive regimen in organ transplantation.
AB - Signaling through the costimulatory pathway is critical in the regulation of T cell activation. Abatacept, a selective costimulatory antagonist FDA approved for the treatment of moderate to severe rheumatoid arthritis, binds to CD80 and CD86 on antigen presenting cells, blocking the interaction with CD28 on T cells. Belatacept, a second generation CTLA4-Ig with 2 amino acid substitutions, has shown considerable promise in clinical transplantation as part of a maintenance immunosuppression regimen. This review will summarize the role of costimulation in T cell activation, detail the development of costimulation antagonists and highlight the pertinent clinical trials completed and ongoing utilizing belatacept as part of an immunosuppressive regimen in organ transplantation.
KW - Belatacept
KW - Costimulation
KW - Kidney transplant
UR - http://www.scopus.com/inward/record.url?scp=80052901571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052901571&partnerID=8YFLogxK
U2 - 10.1016/j.smim.2011.07.002
DO - 10.1016/j.smim.2011.07.002
M3 - Review article
C2 - 21856169
AN - SCOPUS:80052901571
SN - 1044-5323
VL - 23
SP - 157
EP - 164
JO - Seminars in Immunology
JF - Seminars in Immunology
IS - 3
ER -