CEST and PARACEST MR contrast agents

Ileana Hancu; W. Thomas Dixon; Mark Woods; Elena Vinogradov; A. Dean Sherry; Robert E. Lenkinski

doi:10.3109/02841851.2010.502126

CEST and PARACEST MR contrast agents

Ileana Hancu, W. Thomas Dixon, Mark Woods, Elena Vinogradov, A. Dean Sherry, Robert E. Lenkinski

Research output: Contribution to journal › Review article › peer-review

111 Scopus citations

Abstract

In this review we describe the status of development for a new class of magnetic resonance (MR) contrast agents, based on chemical exchange saturation transfer (CEST). The mathematics and physics relevant to the description of the CEST effect in MR are presented in an appendix published in the online version only. We discuss the issues arising when translating in vitro results obtained with CEST agents to using these MR agents in in vivo model studies and in humans. Examples are given on how these agents are imaged in vivo. We summarize the status of development of these CEST agents, and speculate about the next steps that may be taken towards the demonstration of CEST MR imaging in clinical applications.

Original language	English (US)
Pages (from-to)	910-923
Number of pages	14
Journal	Acta Radiologica
Volume	51
Issue number	8
DOIs	https://doi.org/10.3109/02841851.2010.502126
State	Published - Oct 2010

Keywords

Magnetization transfer
Model studies
Paramagnetic agents
Target image

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Access to Document

10.3109/02841851.2010.502126

Cite this

@article{899ad9d67ca9485ca6799fc575cb3e64,

title = "CEST and PARACEST MR contrast agents",

abstract = "In this review we describe the status of development for a new class of magnetic resonance (MR) contrast agents, based on chemical exchange saturation transfer (CEST). The mathematics and physics relevant to the description of the CEST effect in MR are presented in an appendix published in the online version only. We discuss the issues arising when translating in vitro results obtained with CEST agents to using these MR agents in in vivo model studies and in humans. Examples are given on how these agents are imaged in vivo. We summarize the status of development of these CEST agents, and speculate about the next steps that may be taken towards the demonstration of CEST MR imaging in clinical applications.",

keywords = "Magnetization transfer, Model studies, Paramagnetic agents, Target image",

author = "Ileana Hancu and Dixon, {W. Thomas} and Mark Woods and Elena Vinogradov and Sherry, {A. Dean} and Lenkinski, {Robert E.}",

year = "2010",

month = oct,

doi = "10.3109/02841851.2010.502126",

language = "English (US)",

volume = "51",

pages = "910--923",

journal = "Acta Radiologica",

issn = "0284-1851",

publisher = "SAGE Publications Ltd",

number = "8",

}

TY - JOUR

T1 - CEST and PARACEST MR contrast agents

AU - Hancu, Ileana

AU - Dixon, W. Thomas

AU - Woods, Mark

AU - Vinogradov, Elena

AU - Sherry, A. Dean

AU - Lenkinski, Robert E.

PY - 2010/10

Y1 - 2010/10

N2 - In this review we describe the status of development for a new class of magnetic resonance (MR) contrast agents, based on chemical exchange saturation transfer (CEST). The mathematics and physics relevant to the description of the CEST effect in MR are presented in an appendix published in the online version only. We discuss the issues arising when translating in vitro results obtained with CEST agents to using these MR agents in in vivo model studies and in humans. Examples are given on how these agents are imaged in vivo. We summarize the status of development of these CEST agents, and speculate about the next steps that may be taken towards the demonstration of CEST MR imaging in clinical applications.

AB - In this review we describe the status of development for a new class of magnetic resonance (MR) contrast agents, based on chemical exchange saturation transfer (CEST). The mathematics and physics relevant to the description of the CEST effect in MR are presented in an appendix published in the online version only. We discuss the issues arising when translating in vitro results obtained with CEST agents to using these MR agents in in vivo model studies and in humans. Examples are given on how these agents are imaged in vivo. We summarize the status of development of these CEST agents, and speculate about the next steps that may be taken towards the demonstration of CEST MR imaging in clinical applications.

KW - Magnetization transfer

KW - Model studies

KW - Paramagnetic agents

KW - Target image

UR - http://www.scopus.com/inward/record.url?scp=77956516259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956516259&partnerID=8YFLogxK

U2 - 10.3109/02841851.2010.502126

DO - 10.3109/02841851.2010.502126

M3 - Review article

C2 - 20828299

AN - SCOPUS:77956516259

SN - 0284-1851

VL - 51

SP - 910

EP - 923

JO - Acta Radiologica

JF - Acta Radiologica

IS - 8

ER -

CEST and PARACEST MR contrast agents

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this