Cerebrospinal fluid monoamine metabolites in alcoholic patients who attempt suicide

A. Roy, D. Lamparski, J. De Jong, B. Adinoff, B. Ravitz, D. T. George, D. Nutt, M. Linnoila

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Reduced cerebrospinal fluid (CSF) levels of the serotonin metabolite 5‐hydroxyindoleacetic acid have been reported to be commonly associated with suicidal behaviour. Alcoholics are known to often manifest suicidal behaviour. Therefore, we compared cerebrospinal fluid levels of monoamine metabolites in alcoholics who had (n= 20) and had not (n= 108) attempted suicide and healthy volunteers (n= 30). There were no significant differences among the 3 groups for CSF levels of either 5‐hydroxyindoleacetic acid, the dopamine metabolite homovanillic acid, norepinephrine, or the norepinephrine metabolite 3‐methoxy‐4‐hydroxy‐phenylglycol.

Original languageEnglish (US)
Pages (from-to)58-61
Number of pages4
JournalActa Psychiatrica Scandinavica
Issue number1
StatePublished - Jan 1990


  • alcoholism
  • attempted suicide
  • cerebrospinal fluid
  • monoamine metabolite

ASJC Scopus subject areas

  • Psychiatry and Mental health


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