TY - JOUR
T1 - Cerebrospinal fluid chitinase-3-like protein 1 level is not an independent predictive factor for the risk of clinical conversion in radiologically isolated syndrome
AU - Thouvenot, Eric
AU - Hinsinger, Geoffrey
AU - Demattei, Christophe
AU - Uygunoglu, Ugur
AU - Castelnovo, Giovanni
AU - Pittion-Vouyovitch, Sophie
AU - Okuda, Darin
AU - Kantarci, Orhun
AU - Pelletier, Daniel
AU - Lehmann, Sylvain
AU - Marin, Philippe
AU - Siva, Aksel
AU - Lebrun, Christine
N1 - Funding Information:
The authors thank Dr Sarah Kabani for helpful reading and corrections. E.T. and G.H. contributed equally to this work. The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by the Centre National de la Recherche Scientifique, The Institut National de la Sant? et de la Recherche M?dicale (INSERM), la R?gion Languedoc Roussillon, the Radiologically Isolated Syndrome Consortium and the Soci?t? Fran?aise de la Scl?rose en Plaques (SFSEP).
Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by the Centre National de la Recherche Scientifique, The Institut National de la Santé et de la Recherche Médicale (INSERM), la Région Languedoc Roussillon, the Radiologically Isolated Syndrome Consortium and the Société Française de la Sclérose en Plaques (SFSEP).
Funding Information:
The author(s) declared the following potential conflicts of interest with respect to the research, authorship and/or publication of this article: E.T. has received honoraria, travel grants or research grants from the following pharmaceutical companies: Biogen, Genzyme, Merck Serono, Novartis, Roche and Teva Pharma. D.O. received lecture fees from Acorda Therapeutics, Genentech, Genzyme and TEVA Neuroscience; consulting and advisory board fees from Celgene, EMD Serono, Genentech, Genzyme and Novartis and research support from Biogen. A.S. has received honoraria for educational presentations internationally and at national meetings and at symposia sponsored by Bayer-Schering AG; Merck Serono; Teva Pharma of Turkey; Biogen Idec/ GenPharma of Turkey and Genzyme; consultation fees or travel and registration coverage for attending several national or international congresses or symposia from Merck Serono, Novartis, Genzyme and Roche. C.L. has received honoraria for conferences or advisory boards and travel grants from the following pharmaceutical companies: Biogen, Sanofi Genzyme, Merck, Novartis, Roche and Teva Pharma. G.H., C.D., U.U., G.C., S.P.-V., O.K., D.P., S.L. and P.M. have nothing to disclose.
Publisher Copyright:
© The Author(s), 2018.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. Objective: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. Methods: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs). We analysed the influence of epidemiological, radiological and CSF parameters on the risk of clinical event. Results: A total of 211 patients (71 RIS, 48 CIS, 50 RRMS and 42 SC) were included. CSF CHI3L1 levels were lower in RIS than in RRMS and higher in RIS with positive CSF versus negative CSF and SC. The presence of at least one spinal cord lesion was the only independent predictor of faster conversion to RRMS. Association of high CSF CHI3L1 levels, positive CSF (presence of oligoclonal bands and/or an elevated IgG index) or four Barkhof criteria with any spinal cord lesion showed a tendency for reduced mean conversion time. Conclusion: CSF CHI3L1 correlates with positive CSF but is not an independent predictor of the risk of conversion from RIS to RRMS.
AB - Background: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. Objective: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. Methods: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs). We analysed the influence of epidemiological, radiological and CSF parameters on the risk of clinical event. Results: A total of 211 patients (71 RIS, 48 CIS, 50 RRMS and 42 SC) were included. CSF CHI3L1 levels were lower in RIS than in RRMS and higher in RIS with positive CSF versus negative CSF and SC. The presence of at least one spinal cord lesion was the only independent predictor of faster conversion to RRMS. Association of high CSF CHI3L1 levels, positive CSF (presence of oligoclonal bands and/or an elevated IgG index) or four Barkhof criteria with any spinal cord lesion showed a tendency for reduced mean conversion time. Conclusion: CSF CHI3L1 correlates with positive CSF but is not an independent predictor of the risk of conversion from RIS to RRMS.
KW - Multiple sclerosis
KW - biomarkers
KW - cerebrospinal fluid
KW - diagnosis
KW - prognosis
KW - radiologically isolated syndrome
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U2 - 10.1177/1352458518767043
DO - 10.1177/1352458518767043
M3 - Article
C2 - 29564952
AN - SCOPUS:85044723531
SN - 1352-4585
VL - 25
SP - 669
EP - 677
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 5
ER -