Cerebral blood flow during submaximal and maximal dynamic exercise in humans

S. N. Thomas, T. Schroeder, N. H. Secher, J. H. Mitchell

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98 Scopus citations


Cerebral blood flow (CBF) in humans was measured at rest and during dynamic exercise on a cycle ergometer corresponding to 56% (range 27-85) of maximal O2 uptake (V̇O(2max)). Exercise bouts were performed by 16 male and female subjects, lasted 15 min each, and were carried out in a semisupine position. CBF (133Xe clearance) was expressed as the initial slope index (ISI) and as the first compartment flow (F1). CBF at rest [ISI, 58 (range 45-73); F1, 76 (rang 55-98) ml · 100 g-1 · min-1] increased during exercise [ISI to 79 (57-94) and F1 to 118 (75-164) ml · 100 g-1 · min-1, P < 0.01]. CBF did not differ significantly between work loads from 32 (24-33) to 86% (74-96) of V̇O(2max) (n = 10). During exercise, mean arterial pressure increased from 84 (60-100) to 101 (78-124) Torr (P < 0.01) and PCO2 remained unchanged [5.1 (4.6-5.6) vs 5.4 (4.4-6.3) kPa, n = 6]. These results demonstrate a median increase of 31% (0-87) in CBF by ISI and a median increase of 58% (0-133) in CBF by F1 during dynamic exercise in humans.

Original languageEnglish (US)
Pages (from-to)744-748
Number of pages5
JournalJournal of applied physiology
Issue number2
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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