CENP-T bears the load in mitosis

Yang Yang; Hongtao Yu

doi:10.1038/s41556-018-0241-x

CENP-T bears the load in mitosis

Yang Yang, Hongtao Yu

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

During mitosis, the kinetochore connects chromosomes to spindle microtubules and enables chromosome segregation. A genetic study in vertebrate cells demonstrates phosphorylation-regulated plasticity of kinetochore assembly and highlights the role of the centromere protein T in load-bearing kinetochore–microtubule attachment.

Original language	English (US)
Pages (from-to)	1335-1337
Number of pages	3
Journal	Nature cell biology
Volume	20
Issue number	12
DOIs	https://doi.org/10.1038/s41556-018-0241-x
State	Published - Dec 1 2018

ASJC Scopus subject areas

Cell Biology

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title = "CENP-T bears the load in mitosis",

abstract = "During mitosis, the kinetochore connects chromosomes to spindle microtubules and enables chromosome segregation. A genetic study in vertebrate cells demonstrates phosphorylation-regulated plasticity of kinetochore assembly and highlights the role of the centromere protein T in load-bearing kinetochore–microtubule attachment.",

author = "Yang Yang and Hongtao Yu",

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year = "2018",

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doi = "10.1038/s41556-018-0241-x",

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AU - Yang, Yang

AU - Yu, Hongtao

PY - 2018/12/1

Y1 - 2018/12/1

N2 - During mitosis, the kinetochore connects chromosomes to spindle microtubules and enables chromosome segregation. A genetic study in vertebrate cells demonstrates phosphorylation-regulated plasticity of kinetochore assembly and highlights the role of the centromere protein T in load-bearing kinetochore–microtubule attachment.

AB - During mitosis, the kinetochore connects chromosomes to spindle microtubules and enables chromosome segregation. A genetic study in vertebrate cells demonstrates phosphorylation-regulated plasticity of kinetochore assembly and highlights the role of the centromere protein T in load-bearing kinetochore–microtubule attachment.

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DO - 10.1038/s41556-018-0241-x

M3 - Comment/debate

C2 - 30420663

AN - SCOPUS:85057222408

SN - 1465-7392

VL - 20

SP - 1335

EP - 1337

JO - Nature cell biology

JF - Nature cell biology

IS - 12

ER -

CENP-T bears the load in mitosis

Abstract

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