TY - JOUR
T1 - Cellular Metabolism and Induced Pluripotency
AU - Wu, Jun
AU - Ocampo, Alejandro
AU - Belmonte, Juan Carlos Izpisua
N1 - Funding Information:
We sincerely apologize to colleagues whose work has not been included in this Review due to space limitations. We would like to thank all members of the J.C.I.B. laboratory for their experimental and conceptual contributions, which led to some of the ideas presented in this Review. We would like to thank May Schwarz, David O'Keefe, and Peter Schwarz for critically reading the manuscript. Work in the laboratory of J.C.I.B. was supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002), the Moxie Foundation, the Universidad Católica San Antonio de Murcia (UCAM), and Fundacion Pedro Guillen.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/9/8
Y1 - 2016/9/8
N2 - The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are celebrating in this issue of Cell, represents a landmark discovery in biomedical research. Together with somatic cell nuclear transfer, iPSC generation reveals the remarkable plasticity associated with differentiated cells and provides an unprecedented means for modeling diseases using patient samples. In addition to transcriptional and epigenetic remodeling, cellular reprogramming to pluripotency is also accompanied by a rewiring of metabolic pathways, which ultimately leads to changes in cell identities.
AB - The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are celebrating in this issue of Cell, represents a landmark discovery in biomedical research. Together with somatic cell nuclear transfer, iPSC generation reveals the remarkable plasticity associated with differentiated cells and provides an unprecedented means for modeling diseases using patient samples. In addition to transcriptional and epigenetic remodeling, cellular reprogramming to pluripotency is also accompanied by a rewiring of metabolic pathways, which ultimately leads to changes in cell identities.
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U2 - 10.1016/j.cell.2016.08.008
DO - 10.1016/j.cell.2016.08.008
M3 - Review article
C2 - 27610564
AN - SCOPUS:84986328539
SN - 0092-8674
VL - 166
SP - 1371
EP - 1385
JO - Cell
JF - Cell
IS - 6
ER -