Cellular Metabolism and Induced Pluripotency

Jun Wu, Alejandro Ocampo, Juan Carlos Izpisua Belmonte

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations


The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are celebrating in this issue of Cell, represents a landmark discovery in biomedical research. Together with somatic cell nuclear transfer, iPSC generation reveals the remarkable plasticity associated with differentiated cells and provides an unprecedented means for modeling diseases using patient samples. In addition to transcriptional and epigenetic remodeling, cellular reprogramming to pluripotency is also accompanied by a rewiring of metabolic pathways, which ultimately leads to changes in cell identities.

Original languageEnglish (US)
Pages (from-to)1371-1385
Number of pages15
Issue number6
StatePublished - Sep 8 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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