Cellular metabolism and disease: What do metabolic outliers teach us?

Ralph J. Deberardinis, Craig B. Thompson

Research output: Contribution to journalReview articlepeer-review

550 Scopus citations


An understanding of metabolic pathways based solely on biochemistry textbooks would underestimate the pervasive role of metabolism in essentially every aspect of biology. It is evident from recent work that many human diseases involve abnormal metabolic states - often genetically programmed - that perturb normal physiology and lead to severe tissue dysfunction. Understanding these metabolic outliers is now a crucial frontier in disease-oriented research. This Review discusses the broad impact of metabolism in cellular function and how modern concepts of metabolism can inform our understanding of common diseases like cancer and also considers the prospects of developing new metabolic approaches to disease treatment.

Original languageEnglish (US)
Pages (from-to)1132-1144
Number of pages13
Issue number6
StatePublished - Mar 16 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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