Cellular and molecular advances in elucidating p53 function

Jerry W. Shay; Harold Werbin; Walter D. Funk; Woodring E. Wright

doi:10.1016/0165-1110(92)90003-R

Cellular and molecular advances in elucidating p53 function

Jerry W. Shay, Harold Werbin, Walter D. Funk, Woodring E. Wright

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The finding that in many human tumors there is allelic loss and/or mutations in p53, in combination with recognition that these events may play a role in multi-stage carcinogenesis, has focused considerable interest on this gene. To help keep abreast of this rapidly expanding field, recent experiments on the role and potential regulation of p53 are described: these include discussions of p53 as an anti-proliferative agent, the p53 mutations found in human tumors and tumor cell lines, the conformational states of p53 phosphorylation of p53 by p34^cdc2, and signals for the nuclear localization of p53. p53 may act as a transcriptional activator and the specific DNA sequences to which p53 protein binds are also discussed as is the importance of abrogation of p53 function in overcoming cellular senescence.

Original language	English (US)
Pages (from-to)	163-171
Number of pages	9
Journal	Mutation Research/Reviews in Genetic Toxicology
Volume	277
Issue number	2
DOIs	https://doi.org/10.1016/0165-1110(92)90003-R
State	Published - Aug 1992

Keywords

Allelic loss
Human tumors
Multi-stage carcinogenesis
p53 function

ASJC Scopus subject areas

Toxicology
Genetics

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10.1016/0165-1110(92)90003-R

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title = "Cellular and molecular advances in elucidating p53 function",

abstract = "The finding that in many human tumors there is allelic loss and/or mutations in p53, in combination with recognition that these events may play a role in multi-stage carcinogenesis, has focused considerable interest on this gene. To help keep abreast of this rapidly expanding field, recent experiments on the role and potential regulation of p53 are described: these include discussions of p53 as an anti-proliferative agent, the p53 mutations found in human tumors and tumor cell lines, the conformational states of p53 phosphorylation of p53 by p34cdc2, and signals for the nuclear localization of p53. p53 may act as a transcriptional activator and the specific DNA sequences to which p53 protein binds are also discussed as is the importance of abrogation of p53 function in overcoming cellular senescence.",

keywords = "Allelic loss, Human tumors, Multi-stage carcinogenesis, p53 function",

author = "Shay, {Jerry W.} and Harold Werbin and Funk, {Walter D.} and Wright, {Woodring E.}",

note = "Funding Information: Since the initial observations that SV40 large T-antigen antibodies co-precipitated a cellular protein with an apparent molecular weight of 53 kD (DeLeo et al., 1979; Kress et al., 1979; Lane and Crawford, 1979; Linzer and Levine, 1979), now referred to as p53, the functional aspects of the protein and the regulation of the gene encoding it have been studied intensively. Three converging lines of evidence led to the concept that This work was supported by NIH grants AG07992 and CA50195. Correspondence: Jerry W. Shay, Ph.D., The University of Texas Southwestern Medical Center, Department of Cell Biology and Neurosciences, 5323 Harry Hines Boulevard, Dallas, TX 75235-9039, USA. Tel.: 214-688-3282 Fax: 214-688-8694. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1992",

month = aug,

doi = "10.1016/0165-1110(92)90003-R",

language = "English (US)",

volume = "277",

pages = "163--171",

journal = "Mutation Research/Reviews in Genetic Toxicology",

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PY - 1992/8

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N2 - The finding that in many human tumors there is allelic loss and/or mutations in p53, in combination with recognition that these events may play a role in multi-stage carcinogenesis, has focused considerable interest on this gene. To help keep abreast of this rapidly expanding field, recent experiments on the role and potential regulation of p53 are described: these include discussions of p53 as an anti-proliferative agent, the p53 mutations found in human tumors and tumor cell lines, the conformational states of p53 phosphorylation of p53 by p34cdc2, and signals for the nuclear localization of p53. p53 may act as a transcriptional activator and the specific DNA sequences to which p53 protein binds are also discussed as is the importance of abrogation of p53 function in overcoming cellular senescence.

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Cellular and molecular advances in elucidating p53 function

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