Cell type-specific induction of ferroptosis to boost antitumor immunity

Jiao Liu; Jingbo Li; Rui Kang; Daolin Tang

doi:10.1080/2162402X.2023.2282252

Cell type-specific induction of ferroptosis to boost antitumor immunity

Jiao Liu, Jingbo Li, Rui Kang, Daolin Tang

Research output: Contribution to journal › Letter › peer-review

4 Scopus citations

Abstract

Traditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and effective strategy to enhance ferroptosis-driven antitumor immunity.

Original language	English (US)
Article number	2282252
Journal	OncoImmunology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2023.2282252
State	Published - 2023

Keywords

Drug discovery
GPX4
TRIM25
ferroptosis
immunotherapy

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.1080/2162402X.2023.2282252

Cite this

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title = "Cell type-specific induction of ferroptosis to boost antitumor immunity",

abstract = "Traditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and effective strategy to enhance ferroptosis-driven antitumor immunity.",

keywords = "Drug discovery, GPX4, TRIM25, ferroptosis, immunotherapy",

author = "Jiao Liu and Jingbo Li and Rui Kang and Daolin Tang",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.",

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AU - Liu, Jiao

AU - Li, Jingbo

AU - Kang, Rui

AU - Tang, Daolin

PY - 2023

Y1 - 2023

N2 - Traditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and effective strategy to enhance ferroptosis-driven antitumor immunity.

AB - Traditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and effective strategy to enhance ferroptosis-driven antitumor immunity.

KW - Drug discovery

KW - GPX4

KW - TRIM25

KW - ferroptosis

KW - immunotherapy

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UR - http://www.scopus.com/inward/citedby.url?scp=85177444191&partnerID=8YFLogxK

U2 - 10.1080/2162402X.2023.2282252

DO - 10.1080/2162402X.2023.2282252

M3 - Letter

C2 - 38126037

AN - SCOPUS:85177444191

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JO - OncoImmunology

JF - OncoImmunology

IS - 1

M1 - 2282252

ER -

Cell type-specific induction of ferroptosis to boost antitumor immunity

Abstract

Keywords

ASJC Scopus subject areas

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