Cell forces meet cell metabolism

Tadamoto Isogai; Jin Suk Park; Gaudenz Danuser

doi:10.1038/ncb3542

Cell forces meet cell metabolism

Tadamoto Isogai, Jin Suk Park, Gaudenz Danuser

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Epithelial cells form energetically costly cell-cell adhesions in response to mechanical forces. How cells obtain their energy during this event is unclear. Activity of a key regulator of cell metabolism, the AMP-activated protein kinase (AMPK), is now shown to be mechanoresponsive, and thus can bridge adhesion mechanotransduction and energy homeostasis.

Original language	English (US)
Pages (from-to)	591-593
Number of pages	3
Journal	Nature Cell Biology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1038/ncb3542
State	Published - May 31 2017

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb3542

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title = "Cell forces meet cell metabolism",

abstract = "Epithelial cells form energetically costly cell-cell adhesions in response to mechanical forces. How cells obtain their energy during this event is unclear. Activity of a key regulator of cell metabolism, the AMP-activated protein kinase (AMPK), is now shown to be mechanoresponsive, and thus can bridge adhesion mechanotransduction and energy homeostasis.",

author = "Tadamoto Isogai and Park, {Jin Suk} and Gaudenz Danuser",

year = "2017",

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T1 - Cell forces meet cell metabolism

AU - Isogai, Tadamoto

AU - Park, Jin Suk

AU - Danuser, Gaudenz

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AB - Epithelial cells form energetically costly cell-cell adhesions in response to mechanical forces. How cells obtain their energy during this event is unclear. Activity of a key regulator of cell metabolism, the AMP-activated protein kinase (AMPK), is now shown to be mechanoresponsive, and thus can bridge adhesion mechanotransduction and energy homeostasis.

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DO - 10.1038/ncb3542

M3 - Review article

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SP - 591

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JF - Nature Cell Biology

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Cell forces meet cell metabolism

Abstract

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