TY - JOUR
T1 - Cdc20
T2 - A WD40 Activator for a Cell Cycle Degradation Machine
AU - Yu, Hongtao
N1 - Funding Information:
I thank Maojun Yang for modeling the structure of the WD40 domain of Cdc20 and Steve Elledge and Marc Kirschner for communicating results prior to publication. I apologize to colleagues whose primary research papers are not cited due to space limitations. Work in my laboratory is supported by the National Institutes of Health (GM61542), the W.M. Keck Foundation, the Welch Foundation (I-1441), the Leukemia and Lymphoma Society, and the March of Dimes Foundation.
PY - 2007/7/6
Y1 - 2007/7/6
N2 - Cdc20 is an essential cell-cycle regulator required for the completion of mitosis in organisms from yeast to man and contains at its C terminus a WD40 repeat domain that mediates protein-protein interactions. In mitosis, Cdc20 binds to and activates the ubiquitin ligase activity of a large molecular machine called the anaphase-promoting complex/cyclosome (APC/C) and enables the ubiquitination and degradation of securin and cyclin B, thus promoting the onset of anaphase and mitotic exit. APC/CCdc20 is temporally and spatially regulated during the somatic and embryonic cell cycle by numerous mechanisms, including the spindle checkpoint and the cytostatic factor (CSF). Therefore, Cdc20 serves as an integrator of multiple intracellular signaling cascades that regulate progression through mitosis. This review summarizes recent progress toward the understanding of the functions of Cdc20, the mechanisms by which it activates APC/C, and its regulation by phosphorylation and by association with its binding proteins.
AB - Cdc20 is an essential cell-cycle regulator required for the completion of mitosis in organisms from yeast to man and contains at its C terminus a WD40 repeat domain that mediates protein-protein interactions. In mitosis, Cdc20 binds to and activates the ubiquitin ligase activity of a large molecular machine called the anaphase-promoting complex/cyclosome (APC/C) and enables the ubiquitination and degradation of securin and cyclin B, thus promoting the onset of anaphase and mitotic exit. APC/CCdc20 is temporally and spatially regulated during the somatic and embryonic cell cycle by numerous mechanisms, including the spindle checkpoint and the cytostatic factor (CSF). Therefore, Cdc20 serves as an integrator of multiple intracellular signaling cascades that regulate progression through mitosis. This review summarizes recent progress toward the understanding of the functions of Cdc20, the mechanisms by which it activates APC/C, and its regulation by phosphorylation and by association with its binding proteins.
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U2 - 10.1016/j.molcel.2007.06.009
DO - 10.1016/j.molcel.2007.06.009
M3 - Review article
C2 - 17612486
AN - SCOPUS:34250799719
SN - 1097-2765
VL - 27
SP - 3
EP - 16
JO - Molecular cell
JF - Molecular cell
IS - 1
ER -