Caveolin-1 secreting LNCaP cells induce tumor growth of caveolin-1 negative LNCaP cells in vivo

René Bartz, Jian Zhou, Jer Tsong Hsieh, Yunshu Ying, Weiping Li, Pingsheng Liu

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Caveolin-1 (Cav-1) was originally identified as a structural protein of caveolae, which is a plasma membrane domain that regulates a variety of signaling pathways involved in cell growth and migration. Here, we show that expression of Cav-1 in the Cav-1-deficient human prostate cancer cell line LNCaP both stimulates cell proliferation and promotes tumor growth in nude mice. Unexpectedly, Cav-1 expressing LNCaP (LNCaPCav-1) cells injected into one side of a nude mouse promoted tumor growth of Cav-1 negative LNCaP cells injected on the contralateral side of the same animal. The LNCaP tumors were positive for Cav-1, however, this signal was not caused by migrated LNCaP Cav-1 cells, but we show that this Cav-1 was secreted by the LNCaPCav-1 tumors. We demonstrate that conditioned media from LNCaPCav-1 cells contained Cav-1 that was associated with a lipoprotein particle ranging in size from 15 to 30 nm and a density similar to high density lipoprotein particle. These results suggest that LNCaP Cav-1 cells secreting Cav-1 particle produce an endocrine factor that stimulates tumor growth.

Original languageEnglish (US)
Pages (from-to)520-525
Number of pages6
JournalInternational Journal of Cancer
Issue number3
StatePublished - Feb 1 2008


  • Caveolin-1
  • LNCaP
  • Lipoprotein particle
  • Prostate cancer
  • Secretion

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Caveolin-1 secreting LNCaP cells induce tumor growth of caveolin-1 negative LNCaP cells in vivo'. Together they form a unique fingerprint.

Cite this