Abstract
Caveolin-1 (Cav-1) appears to be both a pathophysiological contributor and a target in different inflammatory and hyperproliferative skin conditions as well as in skin aging. Skin fibroblasts demonstrate an up-regulation of Cav-1 expression both in chronological and UV-induced aging, and such an up-regulation was observed both in vitro and in vivo. Typical alterations in aging skin involve a reduction of the dermis thickness, a significant expansion of the dermal white adipose tissue as well as modifications of the content and distribution of hyaluronan, impairment of autophagic flux, a reduction of collagen expression and an increase in tissue inflammation. All of these phenomena can be connected with changes in Cav-1 expression in the aging skin. Modified expression of Cav-1 can also significantly influence the mechanical properties of individual skin layers, thus changing the total mechanical stability of the layered composite skin/WAT, leading to typical structural modifications of the skin surface in the aging skin. Selective reduction of Cav-1 expression has the potential to exert anti-aging effects on the skin.
Original language | English (US) |
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Article number | 100959 |
Journal | Ageing Research Reviews |
Volume | 55 |
DOIs | |
State | Published - Nov 2019 |
Keywords
- Caveolin-1
- Collagen
- Dermal-epidermal junction
- Dermal-hypodermal junction
- Hyaluronan
- Inflammation
- Skin aging
- TGF-β
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Aging
- Molecular Biology
- Neurology