Catechol-O-methyltransferase activity in erythrocytes of pregnant women

G. William Bates; Clare D. Edman; John C. Porter; Paul C. MacDonald

doi:10.1016/0002-9378(78)90118-7

Catechol-O-methyltransferase activity in erythrocytes of pregnant women

G. William Bates, Clare D. Edman, John C. Porter, Paul C. MacDonald

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. COMT activity measured in erythrocytes (RBC's) of healthy men (No. = 47) and healthy nonpregnant women (No. = 53) was 8.2 ± 0.17 nmoles × ml.^-1 (mean and standard error). The COMT activity in RBC's of healthy pregnant women (No. = 100) was 10.7 ± 0.29 nmoles × ml.^-1 RBC × hr.^-1, a value which is significantly higher than that found in RBC's of men and nonpregnant women (p < 0.001).

Original language	English (US)
Pages (from-to)	555-557
Number of pages	3
Journal	American journal of obstetrics and gynecology
Volume	131
Issue number	5
DOIs	https://doi.org/10.1016/0002-9378(78)90118-7
State	Published - Jul 1 1978

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/0002-9378(78)90118-7

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@article{0a881651b04c406abf2b8e37664c2c1c,

title = "Catechol-O-methyltransferase activity in erythrocytes of pregnant women",

abstract = "Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. COMT activity measured in erythrocytes (RBC's) of healthy men (No. = 47) and healthy nonpregnant women (No. = 53) was 8.2 ± 0.17 nmoles × ml.-1 (mean and standard error). The COMT activity in RBC's of healthy pregnant women (No. = 100) was 10.7 ± 0.29 nmoles × ml.-1 RBC × hr.-1, a value which is significantly higher than that found in RBC's of men and nonpregnant women (p < 0.001).",

author = "Bates, {G. William} and Edman, {Clare D.} and Porter, {John C.} and MacDonald, {Paul C.}",

note = "Funding Information: Re$nint requests: Dr. G. William Bates, Cecil H. and Ida Green Center for Reproductive Biology Sciences, The Univemity of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, Texas 75235. *Postdoctoral trainee supported by National Institutes of Health Training Grant HDO0256.",

year = "1978",

month = jul,

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doi = "10.1016/0002-9378(78)90118-7",

language = "English (US)",

volume = "131",

pages = "555--557",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

publisher = "Mosby Inc.",

number = "5",

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TY - JOUR

T1 - Catechol-O-methyltransferase activity in erythrocytes of pregnant women

AU - Bates, G. William

AU - Edman, Clare D.

AU - Porter, John C.

AU - MacDonald, Paul C.

N1 - Funding Information: Re$nint requests: Dr. G. William Bates, Cecil H. and Ida Green Center for Reproductive Biology Sciences, The Univemity of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, Texas 75235. *Postdoctoral trainee supported by National Institutes of Health Training Grant HDO0256.

PY - 1978/7/1

Y1 - 1978/7/1

N2 - Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. COMT activity measured in erythrocytes (RBC's) of healthy men (No. = 47) and healthy nonpregnant women (No. = 53) was 8.2 ± 0.17 nmoles × ml.-1 (mean and standard error). The COMT activity in RBC's of healthy pregnant women (No. = 100) was 10.7 ± 0.29 nmoles × ml.-1 RBC × hr.-1, a value which is significantly higher than that found in RBC's of men and nonpregnant women (p < 0.001).

AB - Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. COMT activity measured in erythrocytes (RBC's) of healthy men (No. = 47) and healthy nonpregnant women (No. = 53) was 8.2 ± 0.17 nmoles × ml.-1 (mean and standard error). The COMT activity in RBC's of healthy pregnant women (No. = 100) was 10.7 ± 0.29 nmoles × ml.-1 RBC × hr.-1, a value which is significantly higher than that found in RBC's of men and nonpregnant women (p < 0.001).

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U2 - 10.1016/0002-9378(78)90118-7

DO - 10.1016/0002-9378(78)90118-7

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C2 - 677197

AN - SCOPUS:0017806232

SN - 0002-9378

VL - 131

SP - 555

EP - 557

JO - American journal of obstetrics and gynecology

JF - American journal of obstetrics and gynecology

IS - 5

ER -

Catechol-O-methyltransferase activity in erythrocytes of pregnant women

Abstract

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