Catalytic enantioselective allylic amination of unactivated terminal olefins via an Ene reaction/[2,3]-rearrangement

Hongli Bao; Uttam K. Tambar

doi:10.1021/ja307851b

Catalytic enantioselective allylic amination of unactivated terminal olefins via an Ene reaction/[2,3]-rearrangement

Hongli Bao, Uttam K. Tambar

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66 Scopus citations

Abstract

The enantioselective allylic amination of unactivated terminal olefins represents a direct and attractive strategy for the synthesis of enantioenriched amines. We have developed the first use of a nitrogen-containing reagent and a chiral palladium catalyst to convert unfunctionalized olefins into enantioenriched allylic amines via an ene reaction/[2,3]-rearrangement.

Original language	English (US)
Pages (from-to)	18495-18498
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	134
Issue number	45
DOIs	https://doi.org/10.1021/ja307851b
State	Published - Nov 14 2012

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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abstract = "The enantioselective allylic amination of unactivated terminal olefins represents a direct and attractive strategy for the synthesis of enantioenriched amines. We have developed the first use of a nitrogen-containing reagent and a chiral palladium catalyst to convert unfunctionalized olefins into enantioenriched allylic amines via an ene reaction/[2,3]-rearrangement.",

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Catalytic enantioselective allylic amination of unactivated terminal olefins via an Ene reaction/[2,3]-rearrangement

Abstract

ASJC Scopus subject areas

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