Abstract
Cryptosporidial diarrhea is uncommon in immunocompetent individuals, more often seen in severely immunocompromised patients. Severe refractory cases have been described in patients with HIV/AIDS before the advent of modern antiretroviral therapy due to an inability to mount an adequate cellular immune response. We describe an 85-year-old patient post–chimeric antigen receptor T-cell therapy relapsed lymphoma who developed refractory Cryptosporidium spp. diarrhea in the setting of persistent CD41 cytopenia. Despite receiving multiple antiparasitic agents, including failure of a prolonged course of nitazoxanide, the patient experienced persistent symptoms for 9 months with repeatedly positivity stool Cryptosporidium spp. direct fluorescent antibody (DFA) test. We highlight this case of refractory Cryptosporidium spp. and the importance of recognizing the pathogen in a non–HIV-infected immunosuppressed host.
Original language | English (US) |
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Pages (from-to) | 651 |
Number of pages | 1 |
Journal | American Journal of Tropical Medicine and Hygiene |
Volume | 105 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2021 |
Externally published | Yes |
ASJC Scopus subject areas
- Parasitology
- Virology
- Infectious Diseases