TY - JOUR
T1 - CARE4Kids Study
T2 - Endophenotypes of Persistent Post-Concussive Symptoms in Adolescents: Study Rationale and Protocol
AU - CARE4Kids Research Consortium
AU - Giza, Christopher C.
AU - Gioia, Gerard
AU - Cook, Lawrence J.
AU - Asarnow, Robert
AU - Snyder, Aliyah
AU - Babikian, Talin
AU - Thompson, Paul
AU - Bazarian, Jeffery J.
AU - Whitlow, Christopher T.
AU - Miles, Christopher M.
AU - Otallah, Scott
AU - Kamins, Joshua
AU - Didehbani, Nyaz
AU - Rosenbaum, Philip E.
AU - Chrisman, Sara P.D.
AU - Vaughan, Christopher G.
AU - Cullum, Munro
AU - Popoli, David M.
AU - Choe, Meeryo
AU - Gill, Jessica
AU - Dennis, Emily L.
AU - Donald, Christine L.Mac
AU - Rivara, Frederick P.
N1 - Publisher Copyright:
© Christopher C. Giza et al., 2023.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Treatment of youth concussion during the acute phase continues to evolve, and this has led to the emergence of guidelines to direct care. While symptoms after concussion typically resolve in 14-28 days, a portion (~20%) of adolescents endorse persistent post-concussive symptoms (PPCS) beyond normal resolution. This report outlines a study implemented in response to the National Institute of Neurological Diseases and Stroke call for the development and initial clinical validation of objective biological measures to predict risk of PPCS in adolescents. We describe our plans for recruitment of a Development cohort of 11- to 17-year-old youth with concussion, and collection of autonomic, neurocognitive, biofluid, and imaging biomarkers. The most promising of these measures will then be validated in a separate Validation cohort of youth with concussion, and a final, clinically useful algorithm will be developed and disseminated. Upon completion of this study, we will have generated a battery of measures predictive of high risk for PPCS, which will allow for identification and testing of interventions to prevent PPCS in the most high-risk youth.
AB - Treatment of youth concussion during the acute phase continues to evolve, and this has led to the emergence of guidelines to direct care. While symptoms after concussion typically resolve in 14-28 days, a portion (~20%) of adolescents endorse persistent post-concussive symptoms (PPCS) beyond normal resolution. This report outlines a study implemented in response to the National Institute of Neurological Diseases and Stroke call for the development and initial clinical validation of objective biological measures to predict risk of PPCS in adolescents. We describe our plans for recruitment of a Development cohort of 11- to 17-year-old youth with concussion, and collection of autonomic, neurocognitive, biofluid, and imaging biomarkers. The most promising of these measures will then be validated in a separate Validation cohort of youth with concussion, and a final, clinically useful algorithm will be developed and disseminated. Upon completion of this study, we will have generated a battery of measures predictive of high risk for PPCS, which will allow for identification and testing of interventions to prevent PPCS in the most high-risk youth.
KW - MRI
KW - adolescent
KW - autonomic nervous system
KW - biomarker
KW - blood
KW - endophenotype
KW - persistent postconcussion symptoms
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UR - http://www.scopus.com/inward/citedby.url?scp=85171383594&partnerID=8YFLogxK
U2 - 10.1089/neu.2023.0073
DO - 10.1089/neu.2023.0073
M3 - Article
C2 - 37463061
AN - SCOPUS:85171383594
SN - 0897-7151
VL - 41
SP - 171
EP - 185
JO - Journal of neurotrauma
JF - Journal of neurotrauma
IS - 1-2
ER -