Cardiac transplantation for hypertrophic cardiomyopathy in the United States 2003-2011

Srilakshmi Vallabhaneni, Amitoj Singh, Srinidhi J. Meera, Jamshid Shirani

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Cardiac transplant (CT) is the sole option in a minority of hypertrophic cardiomyopathy (HC) adults with refractory symptoms or end-stage disease. Aims/Methods: We aimed to examine the trends and hospital outcomes of CT in HC using 2003-2011 Nationwide Inpatient Sample database. Results: HC comprised 1.1% of CT (151 of 14,277) performed during this time period (age 45±12 years, 67% male, 79% Caucasians). Number of HC CT increased from 2003 to 2011 (odds ratio=1.174; 95% confidence interval=1.102-1.252; P< 0.001). Comorbidities included congestive heart failure (76%), hypertension (23%), chronic kidney disease (23%), hyperlipidemia (19%), diabetes (13%), and coronary artery disease (10%). Acute in-hospital major adverse events occurred in 1 in 4 (23%) patient and 1 in 25 (3.8%) patients died perioperatively. Other major adverse events included allograft rejection or vasculopathy (23%), postoperative stroke or transient ischemic attack (3.5%), acute renal failure (43%), respiratory failure requiring mechanical ventilation (13%), sepsis (10%) or need for blood transfusion (10%). Compared to 1990-2004 United Network of Organ Sharing registry data (n=303), patients in current cohort had more comorbid conditions [diabetes (13%-vs-0%); chronic obstructive lung disease (9%-vs-1%); P < 0.001 for both), were more likely to be male (66%-vs-48% P< 0.001), were less likely to be Caucasian (79%-vs-86%; P < 0.001) or smokers (3%-vs-17%; P < 0.001) and less often required perioperative circulatory support or hemodialysis (17%-vs-49%, P < 0.001 and 3.2%-vs-8.3%, P = 0.04, respectively). Conclusion: HC comprises a small proportion of patients undergoing CT. The annual number of CT in HC has increased in recent years at least in part due to inclusion of patients with more comorbid conditions. Transplant recipients in the current cohort, however, required less postoperative circulatory support or renal replacement therapy.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalInternational Journal of Critical Illness and Injury Science
Issue number3
StatePublished - Jul 1 2020
Externally publishedYes


  • Cardiac transplant
  • hypertrophic cardiomyopathy
  • major adverse cardiac events
  • mortality
  • national inpatient sample
  • prognosis

ASJC Scopus subject areas

  • Emergency Medicine
  • Public Health, Environmental and Occupational Health
  • Critical Care and Intensive Care Medicine


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