Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia

Roger G. Linington; Marilyn Robertson; Annick Gauthier; B. Brett Finlay; John B. MacMillan; Tadeusz F. Molinski; Rob Van Soest; Raymond J. Andersen

doi:10.1021/np050192h

Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia

Roger G. Linington, Marilyn Robertson, Annick Gauthier, B. Brett Finlay, John B. MacMillan, Tadeusz F. Molinski, Rob Van Soest, Raymond J. Andersen

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

A screening program aimed at discovering inhibitors of the bacterial type III secretion system identified the MeOH extract of the Caribbean sponge Caminus sphaeroconia as an active hit in the initial assay. Bioassay-guided fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.

Original language	English (US)
Pages (from-to)	173-177
Number of pages	5
Journal	Journal of Natural Products
Volume	69
Issue number	2
DOIs	https://doi.org/10.1021/np050192h
State	Published - Feb 1 2006

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np050192h

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abstract = "A screening program aimed at discovering inhibitors of the bacterial type III secretion system identified the MeOH extract of the Caribbean sponge Caminus sphaeroconia as an active hit in the initial assay. Bioassay-guided fractionation of the crude extract led to the isolation of caminosides A (1) to D (4), a family of antimicrobial glycolipids. The structures of the three new caminosides B (2) to D (4) have been elucidated by spectroscopic analysis.",

author = "Linington, {Roger G.} and Marilyn Robertson and Annick Gauthier and Finlay, {B. Brett} and MacMillan, {John B.} and Molinski, {Tadeusz F.} and {Van Soest}, Rob and Andersen, {Raymond J.}",

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AU - Linington, Roger G.

AU - Robertson, Marilyn

AU - Gauthier, Annick

AU - Finlay, B. Brett

AU - MacMillan, John B.

AU - Molinski, Tadeusz F.

AU - Van Soest, Rob

AU - Andersen, Raymond J.

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Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia

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