Calculation of empirical and true maintenance coefficients by flux balance analysis

Hongwu Ma, Xueming Zhao, Xiaofeng Guo

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The stoichiometric matrix of a simplified metabolic network in Bacillus Subtillis was constructed from the flux balance equations, which were used for reconciliation of the measured rates and determination of the inner metabolic rates. Thus more reliable results of the true and empirical maintenance coefficients were obtained. The true maintenance coefficient is linearly related to the specific growth rate and changes with the P/O ratio. The measured biomass yield of adenosine triphosphate (ATP) is also linearly related to the P/O ratio.

Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalChinese Journal of Chemical Engineering
Issue number1
StatePublished - Feb 1 2002


  • Biomass yield
  • Flux balance analysis
  • Maintenance coefficient
  • Metabolic network

ASJC Scopus subject areas

  • Environmental Engineering
  • Biochemistry
  • Chemistry(all)
  • Chemical Engineering(all)


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