Calcium‐Dependent Proteases in Neuroblastoma Cells

G. N. DeMartino, D. E. Croall

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Abstract: Extracts of neuroblastoma cells contained calcium‐dependent proteolytic activity. This activity was accounted for by two distinct proteases. These proteases were separated by ion‐exchange chromatography. Although each was totally dependent on calcium, the calcium requirements of the enzymes were different; one enzyme required approximately 40 μM Ca2+ for half‐maximal activity and the other enzyme required approximately 150 μM Ca2+ for half‐maximal activity.

Original languageEnglish (US)
Pages (from-to)1642-1648
Number of pages7
JournalJournal of Neurochemistry
Issue number6
StatePublished - Jun 1982


  • Calcium
  • Neuroblastoma
  • Neurofilaments
  • Proteases
  • Protein degradation

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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