Abstract
Since 1999, Caenorhabditis elegans has been extensively used to study microbe-host interactions due to its simple culture, genetic tractability, and susceptibility to numerous bacterial and fungal pathogens. In contrast, virus studies have been hampered by a lack of convenient virus infection models in nematodes. The recent discovery of a natural viral pathogen of C. elegans and development of diverse artificial infection models are providing new opportunities to explore virushost interplay in this powerful model organism.
Original language | English (US) |
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Article number | e00509-17 |
Journal | Journal of virology |
Volume | 91 |
Issue number | 23 |
DOIs | |
State | Published - Dec 1 2017 |
Keywords
- Caenorhabditis elegans
- Flock House virus
- Innate immunity
- Orsay virus
- RNA interference
- Vesicular stomatitis virus
- Virus-host interactions
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology