Buspirone, a non-benzodiazepine anxiolytic, increases locus coeruleus noradrenergic neuronal activity

Manjit K. Sanghera; Brian A. Mcmillen; Dwight C. German

doi:10.1016/0014-2999(82)90406-X

Buspirone, a non-benzodiazepine anxiolytic, increases locus coeruleus noradrenergic neuronal activity

Manjit K. Sanghera, Brian A. Mcmillen, Dwight C. German

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

It has been hypothesized that treatments which increase locus coeruleus (LC) noradrenergic neuronal activity produce anxiety, whereas treatments which decrease LC neuronal activity are anxiety-reducing. Although the benzodiazepine anxiolytic diazepam decreases LC neuronal impulse flow and norepinephrine metabolism, the non-benzodiazepine anxiolytic buspirone does the opposite. These data suggest that a reduction in LC output is not a necessary prerequisite for anxiolytic activity.

Original language	English (US)
Pages (from-to)	107-110
Number of pages	4
Journal	European Journal of Pharmacology
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(82)90406-X
State	Published - Dec 17 1982

Keywords

Anxiety
Buspirone
Diazepam
Locus coeruleus
Norepinephrine

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(82)90406-X

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title = "Buspirone, a non-benzodiazepine anxiolytic, increases locus coeruleus noradrenergic neuronal activity",

abstract = "It has been hypothesized that treatments which increase locus coeruleus (LC) noradrenergic neuronal activity produce anxiety, whereas treatments which decrease LC neuronal activity are anxiety-reducing. Although the benzodiazepine anxiolytic diazepam decreases LC neuronal impulse flow and norepinephrine metabolism, the non-benzodiazepine anxiolytic buspirone does the opposite. These data suggest that a reduction in LC output is not a necessary prerequisite for anxiolytic activity.",

keywords = "Anxiety, Buspirone, Diazepam, Locus coeruleus, Norepinephrine",

author = "Sanghera, {Manjit K.} and Mcmillen, {Brian A.} and German, {Dwight C.}",

note = "Funding Information: This research was supported by USPHS grants MH-30546 and MH-33513. The authors wish to thank Ms. Kathy McDer-mott for the histological work, and Ms. Laura Boynton for typing the manuscript.",

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AU - Sanghera, Manjit K.

AU - Mcmillen, Brian A.

AU - German, Dwight C.

N1 - Funding Information: This research was supported by USPHS grants MH-30546 and MH-33513. The authors wish to thank Ms. Kathy McDer-mott for the histological work, and Ms. Laura Boynton for typing the manuscript.

PY - 1982/12/17

Y1 - 1982/12/17

N2 - It has been hypothesized that treatments which increase locus coeruleus (LC) noradrenergic neuronal activity produce anxiety, whereas treatments which decrease LC neuronal activity are anxiety-reducing. Although the benzodiazepine anxiolytic diazepam decreases LC neuronal impulse flow and norepinephrine metabolism, the non-benzodiazepine anxiolytic buspirone does the opposite. These data suggest that a reduction in LC output is not a necessary prerequisite for anxiolytic activity.

AB - It has been hypothesized that treatments which increase locus coeruleus (LC) noradrenergic neuronal activity produce anxiety, whereas treatments which decrease LC neuronal activity are anxiety-reducing. Although the benzodiazepine anxiolytic diazepam decreases LC neuronal impulse flow and norepinephrine metabolism, the non-benzodiazepine anxiolytic buspirone does the opposite. These data suggest that a reduction in LC output is not a necessary prerequisite for anxiolytic activity.

KW - Anxiety

KW - Buspirone

KW - Diazepam

KW - Locus coeruleus

KW - Norepinephrine

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Buspirone, a non-benzodiazepine anxiolytic, increases locus coeruleus noradrenergic neuronal activity

Abstract

Keywords

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