The construction of the fragments C1-C9 3 and C17-C27 4a of the bryostatins in an enantioselective and highly diastereoselective fashion is described. The usefulness of the 'chiron' approach is illustrated with the synthesis of these fragments from, respectively, D-pantolactone (6) and D-isobutyl lactate (23) as chiral templates.
- D-isobutyl lactate
- aldol and reduction reactions
- diastereoselectivity in alkylation
- marine natural products
ASJC Scopus subject areas
- Organic Chemistry