Abstract
Like phosphorylation, protein sumoylation likely represents a dynamic PTM to alter protein function in support of cell regulatory systems. The broad-spectrum impact of transient or chronic engagement of signal transduction cascades on protein sumoylation has not been explored. Here, we find that epidermal growth factor (EGF) stimulation evokes a rapid alteration in small ubiquitin modifier (SUMO) target selection, while oncogene expression alters steady-state SUMO-protein profiles. A proteomic SUMO target analysis in melanoma cells identified proteins involved in cellular signaling, growth control, and neural differentiation.
Original language | English (US) |
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Pages (from-to) | 2216-2221 |
Number of pages | 6 |
Journal | Proteomics |
Volume | 7 |
Issue number | 13 |
DOIs | |
State | Published - Jun 2007 |
Keywords
- BRAF
- Melanoma
- SUMO
- Signal transduction
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology