Breathing new life into the rational design of Alzheimer's therapeutics

Daniel R. Dries; Gang Yu

doi:10.1016/j.cell.2020.12.036

Breathing new life into the rational design of Alzheimer's therapeutics

Daniel R. Dries, Gang Yu

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

γ-secretase is a promising therapeutic target for Alzheimer's disease, but all inhibitors and modulators have failed due to toxicity or low efficacy. In this issue of Cell, Yang et al. provide cryo-EM structures of γ-secretase individually bound to three inhibitors and a modulator, giving new promise to targeting γ-secretase therapeutically.

Original language	English (US)
Pages (from-to)	296-298
Number of pages	3
Journal	Cell
Volume	184
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2020.12.036
State	Published - Jan 21 2021

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2020.12.036

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title = "Breathing new life into the rational design of Alzheimer's therapeutics",

abstract = "γ-secretase is a promising therapeutic target for Alzheimer's disease, but all inhibitors and modulators have failed due to toxicity or low efficacy. In this issue of Cell, Yang et al. provide cryo-EM structures of γ-secretase individually bound to three inhibitors and a modulator, giving new promise to targeting γ-secretase therapeutically.",

author = "Dries, {Daniel R.} and Gang Yu",

note = "Funding Information: This work was partially supported by NIH grants RF1AG064909 and R01NS079796 . Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

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AB - γ-secretase is a promising therapeutic target for Alzheimer's disease, but all inhibitors and modulators have failed due to toxicity or low efficacy. In this issue of Cell, Yang et al. provide cryo-EM structures of γ-secretase individually bound to three inhibitors and a modulator, giving new promise to targeting γ-secretase therapeutically.

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Breathing new life into the rational design of Alzheimer's therapeutics

Abstract

ASJC Scopus subject areas

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