TY - JOUR
T1 - Brain gray matter phenotypes across the psychosis dimension
AU - Ivleva, Elena I.
AU - Bidesi, Anup S.
AU - Thomas, Binu P.
AU - Meda, Shashwath A.
AU - Francis, Alan
AU - Moates, Amanda F.
AU - Witte, Bradley
AU - Keshavan, Matcheri S.
AU - Tamminga, Carol A.
N1 - Funding Information:
This work was supported by National Institute of Mental Health (MH077851-01A1, and MH 78113, Bipolar & Schizophrenia Consortium for Parsing Endophenotypes). The NIMH had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the manuscript for publication.
PY - 2012/10/30
Y1 - 2012/10/30
N2 - This study sought to examine whole brain and regional gray matter (GM) phenotypes across the schizophrenia (SZ)-bipolar disorder psychosis dimension using voxel-based morphometry (VBM 8.0 with DARTEL segmentation/normalization) and semi-automated regional parcellation, FreeSurfer (FS 4.3.1/64 bit). 3T T1 MPRAGE images were acquired from 19 volunteers with schizophrenia (SZ), 16 with schizoaffective disorder (SAD), 17 with psychotic bipolar I disorder (BD-P) and 10 healthy controls (HC). Contrasted with HC, SZ showed extensive cortical GM reductions, most pronounced in fronto-temporal regions; SAD had GM reductions overlapping with SZ, albeit less extensive; and BD-P demonstrated no GM differences from HC. Within the psychosis dimension, BD-P showed larger volumes in fronto-temporal and other cortical/subcortical regions compared with SZ, whereas SAD showed intermediate GM volumes. The two volumetric methodologies, VBM and FS, revealed highly overlapping results for cortical GM, but partially divergent results for subcortical volumes (basal ganglia, amygdala). Overall, these findings suggest that individuals across the psychosis dimension show both overlapping and unique GM phenotypes: decreased GM, predominantly in fronto-temporal regions, is characteristic of SZ but not of psychotic BD-P, whereas SAD display GM deficits overlapping with SZ, albeit less extensive.
AB - This study sought to examine whole brain and regional gray matter (GM) phenotypes across the schizophrenia (SZ)-bipolar disorder psychosis dimension using voxel-based morphometry (VBM 8.0 with DARTEL segmentation/normalization) and semi-automated regional parcellation, FreeSurfer (FS 4.3.1/64 bit). 3T T1 MPRAGE images were acquired from 19 volunteers with schizophrenia (SZ), 16 with schizoaffective disorder (SAD), 17 with psychotic bipolar I disorder (BD-P) and 10 healthy controls (HC). Contrasted with HC, SZ showed extensive cortical GM reductions, most pronounced in fronto-temporal regions; SAD had GM reductions overlapping with SZ, albeit less extensive; and BD-P demonstrated no GM differences from HC. Within the psychosis dimension, BD-P showed larger volumes in fronto-temporal and other cortical/subcortical regions compared with SZ, whereas SAD showed intermediate GM volumes. The two volumetric methodologies, VBM and FS, revealed highly overlapping results for cortical GM, but partially divergent results for subcortical volumes (basal ganglia, amygdala). Overall, these findings suggest that individuals across the psychosis dimension show both overlapping and unique GM phenotypes: decreased GM, predominantly in fronto-temporal regions, is characteristic of SZ but not of psychotic BD-P, whereas SAD display GM deficits overlapping with SZ, albeit less extensive.
KW - Bipolar disorder
KW - FreeSurfer
KW - Psychosis
KW - Schizophrenia
KW - Voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=84869803977&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869803977&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2012.05.001
DO - 10.1016/j.pscychresns.2012.05.001
M3 - Article
C2 - 23177922
AN - SCOPUS:84869803977
SN - 0925-4927
VL - 204
SP - 13
EP - 24
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 1
ER -