TY - JOUR
T1 - Bone marrow mesenchymal stem cells
T2 - Fat on and blast off by FGF21
AU - Wan, Yihong
N1 - Funding Information:
I thank all the investigators whose studies contributed to the understanding of BMMSCs but could not be cited here due to space limitation. Y. Wan is a Virginia Murchison Linthicum Scholar in Medical Research. This work was supported by the UT Southwestern Endowed Scholar Startup Fund , CPRIT ( RP100841 ), NIH ( RO1DK089113 ), March of Dimes ( #5-FY10-1 ) and The Welch Foundation ( I-1751 ). I declare that I have no financial conflict of interest.
PY - 2013/3
Y1 - 2013/3
N2 - Bone marrow mesenchymal stem cells (BMMSCs) are multipotent marrow stromal cells with the ability to differentiate into a variety of cell types required for tissue regeneration including osteoblasts and chondrocytes. Thus, they hold tremendous potential as powerful therapeutic strategies for the prevention and treatment of degenerative disorders including osteoporosis and osteoarthritis. The differentiation of BMMSCs into competing lineages such as osteoblasts and marrow adipocytes is regulated by various environmental cues and intrinsic signaling pathways. Here I highlight recent advances in the understanding of BMMSC function and regulation, including the interaction between BMMSCs with the hematopoietic/immune system, and the identification of novel modulators of BMMSC differentiation such as the metabolic hormone fibroblast growth factor 21 (FGF21). These new findings will further elucidate the dynamic regulation of BMMSCs in the pathophysiological control of skeletal homeostasis, and facilitate the clinical applications of BMMSCs in regenerative medicine.
AB - Bone marrow mesenchymal stem cells (BMMSCs) are multipotent marrow stromal cells with the ability to differentiate into a variety of cell types required for tissue regeneration including osteoblasts and chondrocytes. Thus, they hold tremendous potential as powerful therapeutic strategies for the prevention and treatment of degenerative disorders including osteoporosis and osteoarthritis. The differentiation of BMMSCs into competing lineages such as osteoblasts and marrow adipocytes is regulated by various environmental cues and intrinsic signaling pathways. Here I highlight recent advances in the understanding of BMMSC function and regulation, including the interaction between BMMSCs with the hematopoietic/immune system, and the identification of novel modulators of BMMSC differentiation such as the metabolic hormone fibroblast growth factor 21 (FGF21). These new findings will further elucidate the dynamic regulation of BMMSCs in the pathophysiological control of skeletal homeostasis, and facilitate the clinical applications of BMMSCs in regenerative medicine.
KW - Adipocyte
KW - Bone marrow mesenchymal stem cell
KW - FGF21
KW - Osteoblast
KW - PPARγ
UR - http://www.scopus.com/inward/record.url?scp=84872560326&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872560326&partnerID=8YFLogxK
U2 - 10.1016/j.biocel.2012.12.014
DO - 10.1016/j.biocel.2012.12.014
M3 - Short survey
C2 - 23270727
AN - SCOPUS:84872560326
SN - 1357-2725
VL - 45
SP - 546
EP - 549
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 3
ER -