TY - JOUR
T1 - Body Composition, IGF1 Status, and Physical Functionality in Nonagenarians
T2 - Implications for Osteosarcopenia
AU - Poggiogalle, Eleonora
AU - Cherry, Katie E.
AU - Su, L. Joseph
AU - Kim, Sangkyu
AU - Myers, Leann
AU - Welsh, David A.
AU - Jazwinski, S. Michal
AU - Ravussin, Eric
N1 - Publisher Copyright:
© 2018 AMDA – The Society for Post-Acute and Long-Term Care Medicine
PY - 2019/1
Y1 - 2019/1
N2 - Objectives: Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old. Setting and Participants: Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included. Measures: The definition of sarcopenia was based on appendicular lean mass (ALM). Osteoporosis was diagnosed based on bone mineral density (BMD) T score. Four phenotypes were compared: (1) healthy body composition, that is, nonosteoporotic nonsarcopenic (CO, control group), (2) osteoporotic (O, low BMD T score), (3) sarcopenic (S, low ALM), and (4) osteosarcopenic (OS, low BMD T score and low ALM). Sex- and age-specific IGF1–Standard Deviation Scores (SDS) were calculated. The Continuous Scale–Physical Functional Performance (CS-PFP) test was performed. Results: In OS men, IGF1-SDS values (−0.61 ±0.37 vs −0.04 ± 0.52, P =.02) were lower than those in CO males (control group), whereas IGF1-SDS were similar in the 4 body composition phenotypes in women. In men only, ALM was positively associated with IGF1-SDS values (P =.01) independent of age and C-reactive protein concentration. Regarding bone health, we found no association between IGF1-SDS values and BMD. IGF1-SDS was not associated with functional performance (CS-PFP) in men and women. Conclusions/Implications: IGF1 sensitivity in skeletal muscle and bone may differ by sex in the oldest old. IGF1 status did not appear to affect physical functionality. Determinants and clinical and functional characteristics of osteosarcopenia need to be further investigated in order to define conclusive diagnostic criteria.
AB - Objectives: Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old. Setting and Participants: Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included. Measures: The definition of sarcopenia was based on appendicular lean mass (ALM). Osteoporosis was diagnosed based on bone mineral density (BMD) T score. Four phenotypes were compared: (1) healthy body composition, that is, nonosteoporotic nonsarcopenic (CO, control group), (2) osteoporotic (O, low BMD T score), (3) sarcopenic (S, low ALM), and (4) osteosarcopenic (OS, low BMD T score and low ALM). Sex- and age-specific IGF1–Standard Deviation Scores (SDS) were calculated. The Continuous Scale–Physical Functional Performance (CS-PFP) test was performed. Results: In OS men, IGF1-SDS values (−0.61 ±0.37 vs −0.04 ± 0.52, P =.02) were lower than those in CO males (control group), whereas IGF1-SDS were similar in the 4 body composition phenotypes in women. In men only, ALM was positively associated with IGF1-SDS values (P =.01) independent of age and C-reactive protein concentration. Regarding bone health, we found no association between IGF1-SDS values and BMD. IGF1-SDS was not associated with functional performance (CS-PFP) in men and women. Conclusions/Implications: IGF1 sensitivity in skeletal muscle and bone may differ by sex in the oldest old. IGF1 status did not appear to affect physical functionality. Determinants and clinical and functional characteristics of osteosarcopenia need to be further investigated in order to define conclusive diagnostic criteria.
KW - Osteosarcopenia
KW - insulin-like growth factor 1
KW - nonagenarians
KW - physical functionality
UR - http://www.scopus.com/inward/record.url?scp=85054503170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054503170&partnerID=8YFLogxK
U2 - 10.1016/j.jamda.2018.07.007
DO - 10.1016/j.jamda.2018.07.007
M3 - Article
C2 - 30149984
AN - SCOPUS:85054503170
SN - 1525-8610
VL - 20
SP - 70-75.e2
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
IS - 1
ER -