Blocking skeletal muscle DHPRS/RYR1 prevents neuromuscular synapse loss in mutant mice deficient in type III neuregulin 1 (CRD-NRG1)

Medicine & Life Sciences

• Neuregulin-1 100%
• Muscle Denervation 87%
• Schwann Cells 79%
• Synapses 65%
• Ryanodine Receptor Calcium Release Channel 58%
• Skeletal Muscle 56%
• Muscles 42%
• Cholinergic Receptors 39%
• mouse ryanodine receptor 1 26%
• Synaptosomal-Associated Protein 25 18%
• L-Type Calcium Channels 15%
• Choline O-Acetyltransferase 14%
• Neuromuscular Junction 13%
• Presynaptic Terminals 13%
• Cellular Structures 12%
• Vertebrates 10%
• Genes 4%

Agriculture & Biology

• synapse 80%
• skeletal muscle 64%
• Schwann cells 52%
• muscles 46%
• ryanodine receptors 45%
• mutants 41%
• mice 40%
• cholinergic receptors 25%
• preserves 12%
• choline acetyltransferase 8%
• genetic engineering 6%
• nerve tissue 5%
• vertebrates 4%
• receptors 4%
• genes 2%
• proteins 2%

Earth & Environmental Sciences

• mutant 74%
• muscle 62%
• loss 37%
• cell 23%
• preserve 11%
• vertebrate 5%
• gene 4%
• protein 4%
• effect 1%