Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment in rodents

Medicine & Life Sciences

• EphB1 Receptor 100%
• Bone Neoplasms 61%
• Cancer Pain 59%
• Morphine 46%
• Analgesics 42%
• Rodentia 41%
• Spinal Cord 40%
• Matrix Metalloproteinase 2 12%
• Hyperalgesia 11%
• Matrix Metalloproteinase 9 11%
• Pain 9%
• Therapeutics 8%
• Up-Regulation 7%
• Ligands 7%
• Down-Regulation 7%
• Bone and Bones 6%
• Spinal Cord Dorsal Horn 6%
• Sensory Receptor Cells 5%
• N-Methyl-D-Aspartate Receptors 5%
• Tibia 5%
• Astrocytes 5%
• Phosphorylation 3%
• Neoplasms 3%
• Mutation 3%